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TranscriptomicsMiRNA expression in perinatal rat pancreas
To investigate the expression of pancreatic miRNAs during the period of perinatal beta-cell expansion and maturation in rats, RNA was extracted from whole pancreas at embryonic day 20 (E20), on the day of birth (P0) and two days after birth (P2) and hybridized to miRCURY LNA microRNA Arrays ver.8.1...
ORGANISM(S): Rattus norvegicus 
2011-08-11 | E-MTAB-594 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pancreas from Wistar or WBN/Kob rats to study chronic pancreatitis
Wistar rats, purchased from BRL (Fullinsdorf/BL, Switzerland), and WBN/Kob rats, purchased from SLC Inc. (Shizuoka, Japan), were specific pathogen-free. Rats were housed in groups of maximally 4 instandard cages (1,820 cm2 bottom area) and kept in our animal facility for various time periods between...
ORGANISM(S): Rattus norvegicus 
2009-05-15 | E-MEXP-1704 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pancreas from patients with autoimmune pancreatitis and alcohol-induced chronic pancreatitis
Autoimmune pancreatitis (AIP) is a recently identified disease of the pancreas with unknown etiology and antigens. The aim of this study was to determine new target antigens and differentially regulated genes and proteins by means of transcriptomics and proteomics and to validate them in patients wi...
ORGANISM(S): Homo sapiens 
2008-12-31 | E-MEXP-804 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver, pancreas and lung tissue of male SD rats and CRISPR/Cas-9-mediated knockout SD-Nme7-/- male rats
We aimed to compare the transcriptome of liver, pancreas, and lung tissue of adult male SD rats and the novel CRISPR/Cas-9-mediated knockout SD-Nme7-/- adult male rats using Affymetrix Rat Gene 2.1 ST Array Strip. Total RNA was isolated from the liver, pancreas, and lung tissues (RNeasy Mini Kit, Qi...
ORGANISM(S): Rattus norvegicus 
2021-04-06 | E-MTAB-10000 | biostudies-arrayexpress
Proteomicsfetal growth restriction_pancreas_differences in nutritional condition
Quantification of proteins in the pancreas of fetal growth restriction.
ORGANISM(S): Rattus Rattus (black Rat) 
2022-06-07 | PXD026502 | JPOST Repository
TranscriptomicsTranscription profiling of mouse pancreas at embryonic days 14.5 and 16.5 from animals lacking beta-catenin, a mediator of Wnt signaling and a component of the cadherin-catenin epithelial adhesion complex
Beta-catenin is an essential mediator of canonical Wnt signaling and a central component of the cadherin-catenin epithelial adhesion complex. Dysregulation of beta-catenin expression has been described in pancreatic neoplasia. Newly published studies have suggested that beta-catenin is critical for ...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7430 | biostudies-arrayexpress
TranscriptomicsAn RNASeq normal tissue atlas for mouse and rat
The function of a gene is closely connected to its expression specificity across tissues and cell types. RNA-Seq is a powerful quantitative tool to explore genome wide expression. The aim of the present study is to provide a comprehensive RNA-Seq dataset across the same 13 tissues for mouse and rat,...
ORGANISM(S): Rattus norvegicus 
2017-10-25 | E-MTAB-6081 | biostudies-arrayexpress
TranscriptomicsGenome-wide mRNA expression profiles of FACS-enriched rat beta cells freshly isolated from neonatal (postnatal day 2-3) and adult (10 weeks-old) Wistar rats
The lower glucose-responsiveness of neonatal beta cells is generally considered a sign of endocrine immaturity. We compared mRNA profiles of neonatal and 10-weeks old rat beta cells to see how their gene expression changes with functional maturation. Neonatal beta cells showed a lower glucose-induc...
ORGANISM(S): Rattus norvegicus 
2013-08-20 | E-GEOD-47174 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of effect of chronic ethanol consumption on Rattus norvegicus pancreas
Male Wistar rats weighing 90-120 g were acclimatized for one week and fed standard laboratory chow, at which time the animals were divided into two groups. Animals were then pair-fed for 8 weeks a regular laboratory chow and water “ad libitum” or Lieber-DeCarli diet (36% calories from ethanol)....
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-3311 | biostudies-arrayexpress
TranscriptomicsStimulation of Human and Rat Islet β-Cell Proliferation with Retention of Function by Nkx6.1
The homeodomain transcription factor Nkx6.1 plays an important role in pancreatic islet β-cell development, but its effects on adult β-cell function, survival, and proliferation are not well understood. In the present study, we demonstrated that treatment of primary rat pancreatic islets with a cy...
ORGANISM(S): Rattus norvegicus 
2010-05-18 | E-GEOD-13153 | biostudies-arrayexpress
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