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TranscriptomicsTranscription profiling of human airway epithelial cell-conditioned monocyte-derive dendritic cells
Dendritic cells differentiate from their precursors in the airway mucosa under local environmental instruction. Airway epithelial cells (AEC) are a potent source of both pro- and anti-inflammatory mediators and are in intimate contact with intraepithelial DC and their precursors. Thus, AEC are like...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12773 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis reveals high expression of activin A during NK-DC interactions
The interaction of natural killer (NK) cells with dendritic cells (DC) results in reciprocal cell activation through the interaction of membrane proteins and the release of soluble factors. Here we report that in NK-DC cocultures, among a set of 84 cytokines investigated, activin A was the second hi...
ORGANISM(S): Homo sapiens 
2013-11-13 | E-GEOD-52306 | biostudies-arrayexpress
GenomicsFacilitates chromatin transcription complex is a marker and target of aggressive cancers with lower survival rates
The Facilitates Chromatin Transcription (FACT) is involved in chromatin remodeling during transcription, replication and DNA repair and is considered to be an ubiquitously expressed complex that has no known associations with any disease. However, we discovered that FACT is expressed in very limited...
ORGANISM(S): Homo sapiens 
2013-03-22 | E-GEOD-45393 | biostudies-arrayexpress
TranscriptomicsExpression analysis and in silico characterization of intronic long noncoding RNAs in renal cell carcinoma: emerging functional associations
Intronic and intergenic long noncoding RNAs (lncRNAs) are emerging gene expression regulators. The molecular pathogenesis of renal cell carcinoma (RCC) is still poorly understood, and in particular, limited studies are available for intronic lncRNAs expressed in RCC. Microarray experiments were perf...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-40914 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA (10X Chromium) of naked mole rate DMBA/TPA treated or control back skin and matched livers (CRUK A) 2022
We generated single cell transcriptomes from full thickness skin biopsies in naked mole-rat to quantify the skin cell types found in this species (control samples). To study if and how naked mole-rat skin changes upon exposure to a carcinogen, we performed a classical two-stage skin carcinogenesis e...
ORGANISM(S): Heterocephalus glaber 
2023-11-21 | E-MTAB-12451 | biostudies-arrayexpress
TranscriptomicsExpression analysis and in silico characterization of intronic long noncoding RNAs in renal cell carcinoma: emerging functional associations (RCC survival)
Intronic and intergenic long noncoding RNAs (lncRNAs) are emerging gene expression regulators. The molecular pathogenesis of renal cell carcinoma (RCC) is still poorly understood, and in particular, limited studies are available for intronic lncRNAs expressed in RCC. Microarray experiments were perf...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-40912 | biostudies-arrayexpress
ProteomicsExploring the interaction between the SWI/SNF chromatin remodeling complex and the zinc finger factor CTCF
The transcription factor CCCTC-binding factor (CTCF) modulates pleiotropic functions mostly related to gene expression regulation. The role of CTCF in large scale genome organization is also well established. A unifying model to explain relationships between many CTCF-mediated activities involve dir...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022037 | Pride
Ctcf  swi/snf  brg1  mass spectrometry  protein‐protein interaction  brk  transcription factor  chromatin 
TranscriptomicsA gene expression signature from peripheral whole blood for stage I lung adenocarcinoma
Affordable early screening in subjects with high risk of lung cancer has great potential to improve survival from this deadly disease. We measured gene expression from lung tissue and peripheral whole blood (PWB) from adenocarcinoma cases and controls to identify dysregulated lung cancer genes that ...
ORGANISM(S): Homo sapiens 
2011-09-22 | E-GEOD-20189 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of miRNA expression profile during Mycobacterium tuberculosis infection of human primary dendritic cells
Mycobacterium tuberculosis (Mtb) is one of the most successful pathogens in human history and remains the second leading cause of death from an infectious agent worldwide. The major reason of Mtb success principally relies on its ability to perfectly adapt to the host, by establishing latent infecti...
ORGANISM(S): Homo sapiens 
2017-12-12 | E-MTAB-6083 | biostudies-arrayexpress
TranscriptomicsA microarray approach to identify genes involved in seed and mesocarp development in peach
Background Field observations and a few physiological studies pointed out that peach embryogenesis and fruit development are strictly related. In fact, attempts to stimulate parthenocarpic fruit development by means of external tools failed. Moreover, physiological disturbances during the early embr...
ORGANISM(S): Prunus persica 
2011-06-27 | E-GEOD-22582 | biostudies-arrayexpress
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