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TranscriptomicsThe effects of NAC on gene expression in Nkx3.1-/- mouse prostate
We tested the effects of the antioxidant NAC (N-Acetyl-Cysteine) on gene expression in Nkx3.1-deficient mouse prostate. Mice that were homozygous null for Nkx3.1 were given NAC or plain water ad libidum for 13 weeks after weaning. Prostates were collected, RNA was harvested and reverse transcribed, ...
ORGANISM(S): Mus musculus 
2012-10-23 | E-GEOD-40352 | biostudies-arrayexpress
TranscriptomicsResolution of Type 2 Diabetes Following Bariatric Surgery is Associated with Changes in Whole Blood Gene Expression
To investigate the effects of bariatric surgery on gene expression profile changes in whole blood in obese subjects with type 2 diabetes in a pilot study setting. Whole blood from eleven obese subjects with type 2 diabetes was collected in PAXgene tubes prior to and 6-12 months after bariatric surg...
ORGANISM(S): Homo sapiens 
2011-01-06 | E-GEOD-19790 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of inflammatory cistrome reveals AP-1/c-Jun as a key regulator of TNFalpha-mediated triple-negative breast cancer progression [microarray]
Triple-negative breast cancer (TNBC) represents a highly aggressive form of breast cancer with limited treatment options. Proinflammatory cytokines such as TNFalpha can facilitate tumor progression and metastasis. However, our knowledge of the molecular mechanisms underlying TNBC progression mediate...
ORGANISM(S): Homo sapiens 
2016-01-20 | E-GEOD-71915 | biostudies-arrayexpress
TranscriptomicsGenetic Risk Factors for Type 2 Diabetes: A Trans-Regulatory Genetic Architecture?
Transcriptional Profiling of Insulin Sensitive and Insulin Resistant Samples Sixty two participants at the tail ends of the distribution of insulin sensitivity adjusted for age, gender and natural logarithm of BMI for each ethnic group separately. Individuals at tail ends were well matched for age, ...
ORGANISM(S): Homo sapiens 
2013-04-16 | E-GEOD-40234 | biostudies-arrayexpress
TranscriptomicsIdentification of genes induced in P. aeruginosa biofilms by microarray analysis
Transcriptome analysis was applied to characterize the physiological activities of Psuedomonas aeruginosa cells grown for three days in drip flow biofilm reactors when compared to the activities of P. aeruginosa grown planktonically to exponential phase in the same media. Here, rather than examining...
ORGANISM(S): Pseudomonas aeruginosa 
2015-05-11 | E-GEOD-65869 | biostudies-arrayexpress
TranscriptomicsLack of genetic heterogeneity at high-resolution aCGH between primary breast cancers and their paired lymph node metastases
Lymph-node (LN) metastases predict for high recurrence rates in breast cancer patients. Eradication of micro-metastatic tumor cells is the primary goal of adjuvant systemic treatment. Decisions regarding systemic treatment depend largely on primary tumor characteristics rather than on characteristic...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-56765 | biostudies-arrayexpress
TranscriptomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-chip
Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We describe here evidence that promoter-proximal pausing is a general feature of transcription ...
ORGANISM(S): Mus musculus 
2010-04-02 | E-GEOD-20529 | biostudies-arrayexpress
TranscriptomicsBacillus anthracis Stern 34F2 sporulation
Timecourse from log phase growth to sporulation in Bacillus anthracis Stern 34F2
ORGANISM(S): Bacillus anthracis 
2010-06-09 | E-GEOD-840 | biostudies-arrayexpress
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