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TranscriptomicsExpression data from Ezh2 epithelial knock-out mouse lungs at E14.5
Ezh2 epigenetically suppresses developmentally-regulated genes. Ezh2 is highly expressed during development, including in the lung. We knocked out Ezh2 in the developing lung epithelium using a Shh-cre driver which is active in foregut endoderm prior to lung morphogenesis. Many developmentally regul...
ORGANISM(S): Mus musculus 
2015-02-04 | E-GEOD-60660 | biostudies-arrayexpress
TranscriptomicsLong noncoding RNAs are spatially correlated with transcription factors and regulate lung development
To identify potential biological functions for three lncRNAs (NANCI, LL12, and LL34) we used shRNAs to knockdown expression of lncRNAs in MLE12 cells, a cell resembling type two lung epithelial cells. This data set contains the microarrays looking at gene expression. We used biological triplicate fo...
ORGANISM(S): Mus musculus 
2014-07-22 | E-GEOD-52389 | biostudies-arrayexpress
TranscriptomicsPrimary lung fibroblasts treated with hedgehog agonist, purmorphamine
Postnatal tissue quiescence is generally thought to be a default state in the absence of a proliferative stimulus such as injury. We now demonstrate that in the lung, quiescence in the adult is an actively maintained state and is regulated by paracrine hedgehog signaling. Epithelial-specific deletio...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-61026 | biostudies-arrayexpress
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