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TranscriptomicsNovel Transcriptome Profiling Analyses Demonstrate that Selective PPARg Modulators Display Attenuated and Selective Gene Regulatory Activity in Comparison with PPARg Full Agonists
We conducted extensive transcriptome profiling studies to characterize 70 SPPARgMs and seven PPARg full agonists in 3T3-L1 adipocytes, and a subset of these ligands in adipose tissue of diabetic db/db mice. In both cases, the SPPARgMs generated attenuated gene regulatory responses, and their gene ex...
ORGANISM(S): Mus musculus 
2012-06-29 | E-GEOD-31222 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling in the Lungs of Patients with Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer
COPD is a common and disabling lung disease for which very few therapeutic options are currently available. We reasoned that global gene expression profiling of COPD lungs could reveal previously unidentified disease pathways for potential therapeutic interventions. Forty-eight human lung samples we...
ORGANISM(S): Homo sapiens 
2007-11-09 | E-GEOD-8500 | biostudies-arrayexpress
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