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MetabolomicsX-ray Irradiation Suppresses Keloid Growth by Inducing G2/M Arrest via the Phytosphingosine-KIF20A Axis
Keloid radiotherapy is clinically effective but has an incomplete underlying molecular mechanism and limited accessibility; we used X-ray exposure to identify effector pathways replicating its antifibrotic benefits without further radiation. After collecting patient keloid samples, primary human kel...
2026-06-06 | MTBLS14461 | MetaboLights
MetabolomicsA metabolite roadmap of the wood-forming tissue in Populus tremula (UPLC-MS assay; Wood fibre and ray cell tissue)

Wood, or secondary xylem, is the product of xylogenesis, a developmental process that begins with the proliferation of cambial derivatives and ends with mature xylem fibers and vessels with lignified secondary cell walls. Fully mature xylem has undergone a series of cellular processes, including ...

2020-09-01 | MTBLS1831 | MetaboLights
TranscriptomicsSensory ray genes
These experiments were undertaken with the goal of identifying genes whose expression is enriched in or restricted to the sensory rays of the C. elegans male tail. We constructed two mutant strains in which ray development is either compromised (EM672) or enhanced (EM673), and harvested mRNA from ad...
ORGANISM(S): Caenorhabditis elegans 
2006-01-05 | E-GEOD-3979 | biostudies-arrayexpress
MetabolomicsExploiting Vitamin B6 Dependency: BVL3572S Inhibits HisC and AlaA to Kill Mycobacterium tuberculosis

Tuberculosis remains the leading cause of death from a single infectious agent worldwide, and the growing prevalence of multi-drug resistant Mycobacterium tuberculosis (Mtb) underscores the urgent need for antibiotics with novel mechanisms of action. Here, we characterize BVL3572S, a hydroxamic a...

2026-06-23 | MTBLS14782 | MetaboLights
TranscriptomicsCharacterization of protoporphytin IX effects on X-ray irradiation in Hela cells in vitro
Hela cells were used to evaluate the protoporphytin IX (PpIX) effects on X-ray irradiation. Treatment conditions were (1) control group (untreated cells); (2) cells treated with 1 μg /ml PpIX for 6 hours; (3) cells irradiated with 3Gy X-rays; (4) cells treated with 1 μg /ml PpIX for 6 hours prior ...
ORGANISM(S): Homo sapiens 
2015-01-21 | E-GEOD-61805 | biostudies-arrayexpress
GenomicsWhole-genome landscape of histone H2AX and M-NM-3-H2AX
Phosphorylation of the histone variant H2AX forms M-NM-3-H2AX that marks DNA double-strand break (DSB). Here we generated the sequencing-based maps of H2AX and M-NM-3-H2AX positioning in resting and proliferating cells before and after ionizing irradiation. Genome-wide locations of possible endoge...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-25577 | biostudies-arrayexpress
TranscriptomicsExpression data from human unbilical endothelial cells (HUVEC) irradiated with X-ray
To understand the molecular mechanism underlying inflammatory reaction in vascular system post exposure to ionizing radiation, we carried out microarray analysis in HUVEC exposed with X-ray HUVEC were irradiated with X-ray (2.5 Gy) and then cultured for 6, 12, and 24 hr. Total RNA were extracted fro...
ORGANISM(S): Homo sapiens 
2016-01-21 | E-GEOD-76484 | biostudies-arrayexpress
TranscriptomicsFe ions and X-ray radiation exposure of Est2-immortalised human coronary artery endothelial cells - 1 day and 7 days post-irradiation
In recent years there is a growing epidemiological indication of excess risk of cardiovascular disease at low doses of ionizing radiation without a clear-cut threshold. It is proposed that damage to the vascular endothelium is critical in radiation-related cardiovascular diseases. In order to identi...
ORGANISM(S): Homo sapiens 
2017-10-02 | E-MTAB-5754 | biostudies-arrayexpress
UnknownMigration of Hydride, Methyl, and Chloride Ligands between Al and M in (PAlP)M Pincer Complexes (M = Rh or Ir).
Not available
S-EPMC10863399 | biostudies-literature
TranscriptomicsTranscription profiling of rat contusion model treated with clenbuterol, X-ray and tempol
Gene expression analysis after the treatments for functional recovery after contusion injury which are mediated by glutathione Experiment Overall Design: 24 hours after contusion and treatments Experiment Overall Design: Groups include normal, laminectomy, contusion and treatments on contused rats (...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5273 | biostudies-arrayexpress
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