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UnknownAnalysis of glycosylation motifs and glycosyltransferases in Bacteria and Archaea.
The process of glycosylation has been studied extensively in prokaryotes but many questions still remain unanswered. Glycosyltransferase is the enzyme which mediates glycosylation and has its preference for the target glycosylation sites as well as for the type of glycosylation i.e. N-linked and O-l...
S-EPMC3124799 | biostudies-literature
UnknownTuning diffusion coefficient, ionic conductivity, and transference number in rGO/BaCoO3 electrode material for optimized supercapacitor energy storage.
Due to their remarkable cycle stability and outstanding capacitance, ABO3-type perovskite materials have emerged as highly effective electrode materials, delivering remarkable electrochemical performance. In this study, BaCoO3/rGO composites with varying rGO content (0, 5, 10, ...
S-EPMC11855277 | biostudies-literature
UnknownOxidative Stress and Analysis of Selected SNPs of ACHE (rs 2571598), BCHE (rs 3495), CAT (rs 7943316), SIRT1 (rs 10823108), GSTP1 (rs 1695), and Gene GSTM1, GSTT1 in Chronic Organophosphates Exposed Groups from Cameroon and Pakistan.
The detrimental effects of organophosphates (OPs) on human health are thought to be of systemic, i.e., irreversible inhibition of acetylcholinesterase (AChE) at nerve synapses. However, several studies have shown that AChE inhibition alone cannot explain all the toxicological manifestations in prolo...
S-EPMC7503738 | biostudies-literature
UnknownMolecular characterization of human group A rotavirus genotypes circulating in Rawalpindi, Islamabad, Pakistan during 2015-2016.
Group A rotaviruses (RVA) are one of the major causes of acute gastroenteritis (AGE) in young children worldwide. Owing to lack of proper surveillance programs and health facilities, developing countries of Asia and Africa carry a disproportionately heavy share of the RVA disease burden. The aim of ...
S-EPMC6667158 | biostudies-literature
UnknownDesign, synthesis, and biological evaluation of sulfonamide-functionalized pyridine carbothioamides as potent tubulin-targeting anticancer agents.
Pyridine carbothioamides (PCAs) are recognized for their gastric mucosal protective effects and low in vivo toxicity, making them attractive scaffolds for anticancer drug development. In this study, a series of N-phenyl 4-substituted and 2,4-disubstituted PCAs (1-8) incorporating a sul...
S-EPMC12624752 | biostudies-literature
UnknownGenomic insights into Yak (Bos grunniens) adaptations for nutrient assimilation in high-altitudes.
High-altitude environments present formidable challenges for survival and reproduction, with organisms facing limited oxygen availability and scarce nutrient resources. The yak (Bos grunniens), indigenous to the Tibetan Plateau, has notably adapted to these extreme conditions. This study delves into...
S-EPMC10920680 | biostudies-literature
UnknownAutosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2.
The sphingosine-1-phosphate receptors (S1PRs) are a well-studied class of transmembrane G protein-coupled sphingolipid receptors that mediate multiple cellular processes. However, S1PRs have not been previously reported to be involved in the genetic etiology of human traits. S1PR2 lies within the au...
S-EPMC4746333 | biostudies-literature
UnknownDeterminants of Implementation of a Critical Care Registry in Asia: Lessons From a Qualitative Study.

Background

The Collaboration for Research, Implementation, and Training in Critical Care in Asia (CCA) is implementing a critical care registry to capture real-time data to facilitate service evaluation, quality improvement, and clinical studies.

Objective

The purpose of this study is...
S-EPMC10028509 | biostudies-literature
UnknownMetoprolol for the Prevention of Acute Exacerbations of COPD.

Background

Observational studies suggest that beta-blockers may reduce the risk of exacerbations and death in patients with moderate or severe chronic obstructive pulmonary disease (COPD), but these findings have not been confirmed in randomized trials.

Methods

In this prospective, ra...
S-EPMC7416529 | biostudies-literature
UnknownManagement and Outcomes Following Surgery for Gastrointestinal Typhoid: An International, Prospective, Multicentre Cohort Study.

Background

Gastrointestinal perforation is the most serious complication of typhoid fever, with a high disease burden in low-income countries. Reliable, prospective, contemporary surgical outcome data are scarce in these settings. This study aimed to investigate surgical outcomes following s...
S-EPMC6132852 | biostudies-literature
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