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ProteomicsEpitope mapping of SARS-CoV 2 RBDs by hydroxyl radical protein footprinting reveals the importance of including negative antibody controls.
The focus of the present investigation was epitope mapping of a mouse monoclonal antibody to the receptor binding domain of two SARS-CoV-2 spike protein variants (Wild-Type and variant B.1.617.2). The experimental setup utilizing multiple controls allowed for validation of false positive binding on ...
ORGANISM(S): Mus musculus (Mouse) Severe acute respiratory syndrome coronavirus 2 
2025-02-21 | PXD046423 | Pride
Rbd alpha Fenton chemistry Covid-19 Mass spectrometry Rbd delta 
ProteomicsStructural dynamics in the evolution of SARS-CoV-2 spike glycoprotein: HDX-MS analysis of the spike of the original Wuhan isolate, G614 spike mutant, and the isolated ancestral RBD - in apo state and in complex with the ACE2 receptor
The spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediates binding to the ACE2 receptor and subsequent membrane fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 receptor, and an open state that does so but displa...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD039760 | Pride
Sars-cov-2 Spike glycoprotein Hdx-ms 
ProteomicsStructural dynamics in the evolution of SARS-CoV-2 spike glycoprotein: HDX-MS analysis of the spike of alpha, beta, delta and omicron variants - in apo state and in complex with the ACE2 receptor
The spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediates binding to the ACE2 receptor and subsequent membrane fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 receptor, and an open state that does so but displa...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD039762 | Pride
Sars-cov-2 Spike glycoprotein Hdx-ms 
UnknownProtective prototype-Beta and Delta-Omicron chimeric RBD-dimer vaccines against SARS-CoV-2.
Not available
S-EPMC9042943 | biostudies-literature
UnknownReceptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2.
Not available
S-EPMC8733278 | biostudies-literature
UnknownEffect of Delta and Omicron Mutations on the RBD-SD1 Domain of the Spike Protein in SARS-CoV-2 and the Omicron Mutations on RBD-ACE2 Interface Complex.
Not available
S-EPMC9456519 | biostudies-literature
UnknownDevelopment of Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccines with Broad Neutralization against SARS-CoV-2 Delta and Other Variants.
Not available
S-EPMC9008796 | biostudies-literature
ProteomicsAnalysis of N-Glycosylation for SARS-CoV-2 expressed receptor-binding domain VOCs and membrane protein with LC-MS.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect human cells by first attaching to the ACE-2 receptor via its receptor-binding domain (RBD) in the spike protein. We investigated the influence of N-glycosylation sites of the RBD and the membrane (M) protein on IgG antibody bind...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
2024-04-29 | PXD048930 | panorama
UnknownIntranasal VLP-RBD vaccine adjuvanted with BECC470 confers immunity against Delta SARS-CoV-2 challenge in K18-hACE2-mice.
Not available
S-EPMC10300285 | biostudies-literature
UnknownStructural and Energetic Insights into SARS-CoV-2 Evolution: Analysis of hACE2-RBD Binding in Wild-Type, Delta, and Omicron Subvariants.
Not available
S-EPMC12027596 | biostudies-literature
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