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ProteomicsRBM6 proximity interactions (RBM6-APEX)
We sought to map RBM6 interactome using ascorbate peroxidase (APEX2)-based proximity labelling combined with mass spectrometry. Toward this end, we used CRISPR-cas9 methodology to establish MCF10A cell line expressing APEX2 fused to the N-terminal of RBM6, hereafter called MCF10AAPEX2-RBM6. The pero...
ORGANISM(S): Homo sapiens (Human) 
2021-12-29 | PXD024295 | Pride
Rbm6   apex2   proximity interactions 
TranscriptomicsRegulation of NUMB alternative splicing by RBM5, RBM6 and RBM10 controls cancer cell proliferation (CLIP-Seq)
RBM5, a regulator of alternative splicing of apoptotic genes, and its close homologues, RBM6 and RBM10, are RNA binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 and RBM10 antagonistically regulate the proliferative capacity of cancer cells and display distinct pos...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-48066 | biostudies-arrayexpress
TranscriptomicsRegulation of NUMB alternative splicing by RBM5, RBM6 and RBM10 controls cancer cell proliferation
RBM5, a regulator of alternative splicing of apoptotic genes, and its close homologues, RBM6 and RBM10, are RNA binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 and RBM10 antagonistically regulate the proliferative capacity of cancer cells and display distinct pos...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-47431 | biostudies-arrayexpress
GenomicsTranscriptome analysis of control and RBM6 KO cells before and after DNA damage
Transcriptome analysis of control and RBM6 KO cells before and after DNA damage
PRJNA704004 | ENA
UnknownRecruitment of RBM6 to DNA Double-Strand Breaks Fosters Homologous Recombination Repair.
Not available
S-EPMC10038030 | biostudies-literature
GenomicsRBM6 promotes tumor cell apoptosis and disrupts the alternative splicing of related genes in HeLa cells
RBM6 promotes tumor cell apoptosis and disrupts the alternative splicing of related genes in HeLa cells
PRJNA805553 | ENA
TranscriptomicsTranscriptome analysis of control and RBM6 KO cells before and after DNA damage
Control and RBM6-KO MCF10A-Hras cells were subjected to RNA-sequencing before and after 12hrs exposure to 5Gy ionizing radiation (IR). Transcriptome analysis revealed a subset of genes that are differentially regulated in RBM6-KO cells compared to control cells. In addition, transcriptome of RBM6-KO...
ORGANISM(S): Homo sapiens 
2021-03-23 | GSE167265 | GEO
UnknownThe Oncopromoting Gene RBM6 Inhibits Prostate Tumour Cell Migration During Epithelial-to-Mesenchymal Transition.
Not available
S-EPMC11790351 | biostudies-literature
UnknownRBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs.
Not available
S-EPMC8599755 | biostudies-literature
TranscriptomicsRBM6 promotes tumor cell apoptosis and disrupts the alternative splicing of related genes in HeLa cells
RNA binding proteins have important functions in tumorigenesis; therefore, their regulatory mechanisms should be further explored. The present study aimed to determine the regulatory roles of RNA binding motif protein 6 (RBM6) in transcription and alternative splicing in Hela cells. RBM6 expression ...
ORGANISM(S): Homo sapiens 
2023-10-17 | GSE196600 | GEO
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