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TranscriptomicsMicroRNA-Directed siRNA Biogenesis in Caenorhabditis elegans
C.elegans small RNAs from HA::ALG-1, HA::ALG-2 and HA::RDE-1 IP and rde-1 mutants Small RNAs were cloned from transgenic or mutant C. elegans adults. Sequencing was performed using 454 and Illumina platforms.
ORGANISM(S): Caenorhabditis elegans 
2010-04-14 | E-GEOD-20649 | biostudies-arrayexpress
TranscriptomicsThe Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification
From a forward genetic screen for C. elegans genes required for RNAi, we identified rde-10 and through proteomic analysis of RDE-10-interacting proteins, we identified a protein complex containing the new RNAi factor RDE-11, the known RNAi factors RSD-2 and ERGO-1, as well as other candidate RNAi fa...
ORGANISM(S): Caenorhabditis elegans 
2012-04-07 | E-GEOD-37083 | biostudies-arrayexpress
UnknownRDE Treatment Prevents Non-Specific Detection of SARS-CoV-2- and Influenza-Specific IgG Antibodies in Heat-Inactivated Serum Samples.
Not available
S-EPMC10295076 | biostudies-literature
GenomicsRNA-seq of Caenorhabditis elegans (at Late L4 stage) of rrf-3(pk1426) rde-1(ne219) unc-62p::rde-1 and daf-2(e1370) rrf-3(pk1426) rde-1(ne219) unc-62p::rde-1 grown on control RNAi or cyd-1 RNAi.
RNA-seq of Caenorhabditis elegans (at Late L4 stage) of rrf-3(pk1426) rde-1(ne219) unc-62p::rde-1 and daf-2(e1370) rrf-3(pk1426) rde-1(ne219) unc-62p::rde-1 grown on control RNAi or cyd-1 RNAi.
PRJEB64540 | ENA
UnknownAGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals.
Not available
S-EPMC17255 | biostudies-literature
GenomicsThe Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification
From a forward genetic screen for C. elegans genes required for RNAi, we identified rde-10 and through proteomic analysis of RDE-10-interacting proteins, we identified a protein complex containing the new RNAi factor RDE-11, the known RNAi factors RSD-2 and ERGO-1, as well as other candidate RNAi fa...
ORGANISM(S): Caenorhabditis elegans 
2012-04-07 | GSE37083 | GEO
TranscriptomicsTranscriptome analysis of C. elegans embryos lacking ADARs and the 26G pathway
Adenosine deaminases that act on RNA (ADARs) catalyze the conversion of adenosine to inosine in dsRNA. C. elegans ADARs, ADR-1 and ADR-2, promote the expression of genes containing dsRNA structures by preventing their processing into siRNAs and silencing by RNAi. The 26G endogenous siRNA (endo-siRNA...
ORGANISM(S): Caenorhabditis elegans 
2018-02-23 | GSE106647 | GEO
GenomicsMicroRNA-Directed siRNA Biogenesis in Caenorhabditis elegans
C.elegans small RNAs from HA::ALG-1, HA::ALG-2 and HA::RDE-1 IP and rde-1 mutants
ORGANISM(S): Caenorhabditis elegans 
2010-04-14 | GSE20649 | GEO
TranscriptomicsTranscription profiling of C.elegans RNAi defective mutants of rde-1 and rde-4
Microarrays were performed in quadruplicate on 4 strains of adult staged C. elegans (1) N2 Bristol - wildtype (2) rde-1 mutants (3) rde-4 mutants. rde mutants are RNAi defective.
ORGANISM(S): Caenorhabditis elegans 
2009-03-03 | E-MEXP-956 | biostudies-arrayexpress
GenomicsThe Vasa homolog RDE-12 engages target mRNA and a secondary-Argonaute WAGO-1 to promote RNAi in C. elegans
Argonaute proteins (AGOs) are key nuclease effectors of RNA interference (RNAi) [1]. Although purified AGOs can mediate a single round of target-RNA cleavage in vitro, accessory factors are required for siRNA loading and to achieve multiple-target turnover [2, 3]. To identify AGO co-factors we immun...
ORGANISM(S): Caenorhabditis elegans 
2014-06-24 | GSE54396 | GEO
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