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GenomicsEffect of L-Proline on mouse embryonic stem cells (ESCs)
We found that the non-essential amino acid L-proline (L-Pro) acts as a signaling molecule that promotes the conversion of embryonic stem cells (ESCs) into mesenchymal-like, spindle-shaped, highly motile, invasive pluripotent stem cells.This embryonic stem cell-to-mesenchymal-like transition (esMT) i...
ORGANISM(S): Mus musculus 
2013-08-31 | E-GEOD-50477 | biostudies-arrayexpress
GenomicsDiscrete Functions of Rev-erba Couple Metabolism to the Clock [HTS]
Circadian and metabolic physiology are intricately intertwined, as illustrated by Rev-erb , a transcription factor (TF) that functions both as a core repressive component of the cell autonomous clock and as a regulator of metabolic genes. Here we show that Rev-erb modulates the clock and metabolis...
ORGANISM(S): Mus musculus 
2015-06-16 | E-GEOD-67962 | biostudies-arrayexpress
GenomicsRad50 ChIPseq in Drosophila wandering larval central nervous system and in embryos stage 16
Rad50 is overexpressed in larval brain compared to embryo and is likely linked to stage specific chromatin modification. To identify the targets of Rad50, ChIPseq with Rad50 antibody was done in duplicate on wandering larval brain and on embryo stage 16.
ORGANISM(S): Drosophila melanogaster 
2024-12-31 | E-MTAB-12982 | biostudies-arrayexpress
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