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TranscriptomicsDRM complex mutant lin-54 vs. H3K36 methyltransferase mutant mes-4 vs. lin-54; mes-4 double mutant vs. wild type C.elegans germline
Here we uncover antagonistic regulation of transcript levels in the germline of Caenorhabditis elegans hermaphrodites. The histone methyltransferase MES-4 marks genes expressed in the germline with methylated Lys36 on histone H3 (H3K36me) and promotes their transcription; MES-4 also represses genes ...
ORGANISM(S): Caenorhabditis elegans 
2013-11-05 | E-GEOD-52064 | biostudies-arrayexpress
Transcriptomicsmes-2, mes-4 or mes-2; mes-4 mutants vs. wild type
Trascriptional profiling of C. elegans adult germ lines comparing mes-2(bn11)unc-4(e120) mutants and unc-4(e120) (wild type), mes-4(bn85) mutants and N2 (wild type), mes-2(bn11)unc-4(e120); mes-4(bn85) and unc-4(e120) (wild type) at 20 degrees. One-condition experiment, mutant vs. WT. Biological re...
ORGANISM(S): Caenorhabditis elegans 
2012-05-29 | E-GEOD-38158 | biostudies-arrayexpress
TranscriptomicsComparison of transcriptomes of sig-7 (RNAi) vs WT C. elegans early stage embryos by RNA-seq
RNAi targeting a conserved C. elegans cyclophilin, sig-7, causes defective development and embryonic arrest consistent with a global defect in transcription. The goal of this study was to compare the transcript levels in sig-7(RNAi) embryos to those of L4440/RNAi control embryos to examine the globa...
ORGANISM(S): Caenorhabditis elegans 
2016-08-10 | E-GEOD-85442 | biostudies-arrayexpress
Transcriptomicslin-35(n745) mutants vs. wild type
Transcriptional profiling of C. elegans first larval stage whole animals comparing lin-35(n745) mutants and N2 (wild type) at 26 degrees. One-condition experiment, mutant (lin-35) vs. WT. Biological replicates 4 mutant, 4 wildtype harvested indepedently. One lin-35 replicate and one WT replicate p...
ORGANISM(S): Caenorhabditis elegans 
2011-01-25 | E-GEOD-26824 | biostudies-arrayexpress
Transcriptomicslin-15B(n744) mutants vs. wild type
Transcriptional profiling of C. elegans first larval stage whole animals comparing lin-15B(n744) mutants and N2 (wild type) at 26 degrees. One-condition experiment, mutant (lin-15B) vs. WT. Biological replicates 4 mutant, 4 wildtype harvested indepedently. One lin-35 replicate and one WT replicate...
ORGANISM(S): Caenorhabditis elegans 
2011-01-25 | E-GEOD-26823 | biostudies-arrayexpress
Transcriptomicslin-35(n745) mutants vs. lin-35(n745), mes-4(RNAi) (below referred to as reference sample and test sample respectively)
Transcriptional profiling of C. elegans first larval stage whole animals comparing lin-35(n745) mutants and lin-35(n745) treated with mes-4(RNAi) at 26 degrees. One-condition experiment, mutant (lin-35) vs. mutant plus RNAi (lin-35, mes-4RNAi). Biological replicates 4 mutant, 4 mutant plus RNAi har...
ORGANISM(S): Caenorhabditis elegans 
2011-01-25 | E-GEOD-26825 | biostudies-arrayexpress
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