Sort   by:  
 Page size 
TranscriptomicsGenome-Wide Specificity of DNA-Binding, Gene Regulation, and Chromatin Remodeling by TALE- and CRISPR/Cas9-Based Transcription Factors
Synthetic DNA-binding proteins have found broad application in gene therapies and as tools for interrogating biology. Engineered proteins based on the CRISPR/Cas9 and TALE systems have been used to alter genomic DNA sequences, control transcription of endogenous genes, and modify epigenetic states. ...
ORGANISM(S): Homo sapiens 
2015-05-27 | E-GEOD-68341 | biostudies-arrayexpress
UnknownPlacental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.
Not available
S-EPMC3479343 | biostudies-literature
UnknownReply to S.A. Upadhyaya.
Not available
S-EPMC7526718 | biostudies-literature
GenomicsChromatin Remodeling Inactivates Activity Genes and Regulates Neural Coding
Activity-dependent transcription influences neuronal connectivity, but the roles and mechanisms of inactivation of activity-dependent genes have remained poorly understood. Genome-wide analyses in the mouse cerebellum revealed that the nucleosome remodeling and deacetylase (NuRD) complex deposits th...
ORGANISM(S): Mus musculus 
2016-07-18 | E-GEOD-83253 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of M.tuberculosis using RNA-seq indicates WhiB6 repression of dormancy associated genes
Tuberculosis is an infectious disease, with latent infection with Mycobacterium tuberculosis (M.tb) affecting 1/3 of humanity. It can remain quiescent for long time, making eradication very difficult. To do so, M.tb need to carefully orchestrate its gene expression to survive immune response and sta...
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2013-09-18 | E-GEOD-40941 | biostudies-arrayexpress
TranscriptomicsEnhanced MyoD-Induced Transdifferentiation to a Myogenic Lineage by Fusion to a Potent Transactivation Domain
Synthetic transcription factors can be applied to many areas of biotechnology, medicine, and basic research.  Currently, the most common method for engineering synthetic transcription factors has been based on programmable DNA-binding domains of zinc finger proteins, Transcription Activator-Like Ef...
ORGANISM(S): Homo sapiens 
2014-12-11 | E-GEOD-62448 | biostudies-arrayexpress
UnknownRare Variant, Gene-Based Association Study of Hereditary Melanoma Using Whole-Exome Sequencing.
Not available
S-EPMC5939858 | biostudies-literature
UnknownCrowd-sourced machine learning prediction of long COVID using data from the National COVID Cohort Collaborative.
Not available
S-EPMC11462169 | biostudies-literature
GenomicsGenome-Wide Specificity of DNA-Binding, Gene Regulation, and Chromatin Remodeling by TALE- and CRISPR/Cas9-Based Transcription Factors
Synthetic DNA-binding proteins have found broad application in gene therapies and as tools for interrogating biology. Engineered proteins based on the CRISPR/Cas9 and TALE systems have been used to alter genomic DNA sequences, control transcription of endogenous genes, and modify epigenetic states. ...
ORGANISM(S): Homo sapiens 
2015-04-24 | E-GEOD-57085 | biostudies-arrayexpress
TranscriptomicsRNA-Guided Human Gene Activation by Cas9/CRISPR-Based Engineered Transcription Factors
Synthetic transcription factors can be applied in many areas of biotechnology, medicine, and basic research.  In contrast to current methods based on engineering new DNA-binding proteins, we show that Cas9 fused to a transcriptional activation domain can be targeted by combinations of guide RNA mole...
ORGANISM(S): Homo sapiens 
2013-07-25 | E-GEOD-47114 | biostudies-arrayexpress
Sort   by:  
 Page size