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ProteomicsVerazine Biosynthesis from Simple Sugars in Engineered Saccharomyces cerevisiae
Steroidal alkaloids are FDA-approved drugs (e.g., Zytiga) and promising drug candidates/leads (e.g., cyclopamine); yet many of the ≥ 697 known steroidal alkaloid natural products remain underutilized as drugs because it can be challenging to scale their biosynthesis in their producing organisms. Cyc...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-03-08 | PXD053024 | Pride
Verazine  steroidal alkaloid  natural product  microbial biosynthesis  metabolic engineering  synthetic biology 
TranscriptomicsDifferential Expression of Genes Characterizing Muscle Fiber Phenotype in Turkeys
Because of its high plasticity and rapid growth rate, turkey skeletal muscle is an important model for studying mechanisms responsible for vertebrate skeletal muscle development and function. Skeletal muscle is composed of metabolically heterogeneous myofibers that exhibit high plasticity at both ...
ORGANISM(S): Meleagris gallopavo 
2011-01-13 | E-GEOD-23354 | biostudies-arrayexpress
GenomicsChIP-seq for EP300 and H3K4me1 in the mouse melanocyte cell line melan-a
Using ChIP-seq for p300 and H3K4me1, we identified 2,489 putative melanocyte enhancer loci in the mouse genome. We demonstrated that these putative enhancers are evolutionarily constrained, enriched for sequence motifs predicted to bind key melanocyte transcription factors, located near genes releva...
ORGANISM(S): Mus musculus 
2012-09-14 | E-GEOD-38498 | biostudies-arrayexpress
UnknownEvaluation of a proposal for reliable low-cost grid power with 100% wind, water, and solar.
Not available
S-EPMC5495221 | biostudies-literature
TranscriptomicsSingle cell RNA-sequencing of PBMC derived B cells from human healthy donor
Motivation: The B-cell receptor (BCR) performs essential functions for the adaptive immune system including recognition of pathogen-derived antigens. The vast repertoire and adaptive variation of BCR sequences due to V(D)J recombination and somatic hypermutation (SHM) necessitates single-cell charac...
ORGANISM(S): Homo sapiens 
2018-06-22 | E-MTAB-6386 | biostudies-arrayexpress
ModelsFeist2007_EcMetabol_flux1
organism E. coli K-12 MG1655 model iAF1260 Biomass Objective Function (BOF) Ec_biomass_iAF1260_core_59p81M (E. coli biomass objective function (iAF1260) - core - with 59.81 GAM estimate) flux balance analysis objective maximize BOF Growth Associated Maintenance (GAM) 59.81 mmol A...
2005-01-01 | MODEL3023609334 | BioModels
ModelsFeist2007_EcMetabol_flux2
organism E. coli K-12 MG1655 model iAF1260 Biomass Objective Function (BOF) Ec_biomass_iAF1260_core_59p81M (E. coli biomass objective function (iAF1260) - core - with 59.81 GAM estimate) flux balance analysis objective maximize BOF Growth Associated Maintenance (GAM) 59.81 mmol A...
2005-01-01 | MODEL3023641273 | BioModels
GenomicOncoArray: Prostate Cancer

Original description of the study: From ELLIPSE (linked to the PRACTICAL consortium), we contributed ~78,000 SNPs to the OncoArray. A large fraction of the content was derived from the GWAS meta-analyses in European ancestry populations (overall and aggressive disease; ~27K SNPs). We also ...

phs001391 | dbGaP
GenomicsActivation of the Integrated Stress Response by a Jumonji Histone Demethylase Inhibitor Induces Pro-Apoptotic Metabolic Reprogramming in Multiple Myeloma
Regulation of gene expression by chromatin modification through methylation of histone lysine residues is a dynamic, reversible process that when deregulated is associated with cancer development. In multiple myeloma, combined inhibition of the histone demethylases JARID1B, UTX and JmjD3 by the smal...
ORGANISM(S): Homo sapiens 
2015-08-21 | E-GEOD-60626 | biostudies-arrayexpress
UnknownLopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.
Not available
S-EPMC8274471 | biostudies-literature
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