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UnknownAssociation of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer.
Not available
S-EPMC5815405 | biostudies-literature
ProteomicsVerazine Biosynthesis from Simple Sugars in Engineered Saccharomyces cerevisiae
Steroidal alkaloids are FDA-approved drugs (e.g., Zytiga) and promising drug candidates/leads (e.g., cyclopamine); yet many of the ≥ 697 known steroidal alkaloid natural products remain underutilized as drugs because it can be challenging to scale their biosynthesis in their producing organisms. Cyc...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-03-08 | PXD053024 | Pride
Verazine  steroidal alkaloid  natural product  microbial biosynthesis  metabolic engineering  synthetic biology 
UnknownPresence of de novo mutations in autosomal dominant polycystic kidney disease patients without family history.
Not available
S-EPMC2598385 | biostudies-literature
TranscriptomicsSilver Nanowire Exposure Results in Internalization and Toxicity to Daphnia magna
Nanowires (NWs), high-aspect-ratio nanomaterials, are increasingly used in technological materials and consumer products and may have toxicological characteristics distinct from nanoparticles. We carried out a comprehensive evaluation of the physicochemical stability of four silver nanowires (AgNWs)...
ORGANISM(S): Daphnia magna 
2013-12-31 | E-GEOD-47064 | biostudies-arrayexpress
Transcriptomicsp53 and ATF4 Mediate Distinct and Additive Mechanisms to Skeletal Muscle Atrophy During Limb Immobilization
p53 regulates a distinct subset of skeletal muscle mRNAs during immobilization-induced skeletal muscle atrophy For additional details see Fox et al, p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization. Am J Physiol Endocrinol Metab. 2014 Aug 1;30...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-62897 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-sequencing of PBMC derived B cells from human healthy donor
Motivation: The B-cell receptor (BCR) performs essential functions for the adaptive immune system including recognition of pathogen-derived antigens. The vast repertoire and adaptive variation of BCR sequences due to V(D)J recombination and somatic hypermutation (SHM) necessitates single-cell charac...
ORGANISM(S): Homo sapiens 
2018-06-22 | E-MTAB-6386 | biostudies-arrayexpress
TranscriptomicsEffects of ursolic acid and tomatidine on skeletal muscle mRNA expression in aged mice.
For additional details see Ebert et al, Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. Weight-matched cohorts of 22-month-old male C57BL/6 mice were provided ad libitum access to standard chow (control) or standard chow ...
ORGANISM(S): Mus musculus 
2015-09-03 | E-GEOD-72651 | biostudies-arrayexpress
TranscriptomicsEffect of muscle-specific ATF4 gene knockout (ATF4 mKO) on skeletal muscle mRNA levels in aged mice.
For additional details see Ebert et al, Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. Quadriceps femoris muscles were harvested from 22-month-old muscle-specfic ATF4 knockout (ATF4 mKO) mice and littermate controls. mR...
ORGANISM(S): Mus musculus 
2015-09-03 | E-GEOD-72658 | biostudies-arrayexpress
ModelsFeist2007_EcMetabol_flux1
organism E. coli K-12 MG1655 model iAF1260 Biomass Objective Function (BOF) Ec_biomass_iAF1260_core_59p81M (E. coli biomass objective function (iAF1260) - core - with 59.81 GAM estimate) flux balance analysis objective maximize BOF Growth Associated Maintenance (GAM) 59.81 mmol A...
2005-01-01 | MODEL3023609334 | BioModels
ModelsFeist2007_EcMetabol_flux2
organism E. coli K-12 MG1655 model iAF1260 Biomass Objective Function (BOF) Ec_biomass_iAF1260_core_59p81M (E. coli biomass objective function (iAF1260) - core - with 59.81 GAM estimate) flux balance analysis objective maximize BOF Growth Associated Maintenance (GAM) 59.81 mmol A...
2005-01-01 | MODEL3023641273 | BioModels
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