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MetabolomicsGut microbiota-derived deoxycholic acid promotes pancreatic regeneration following acute pancreatitis via Reg3a signaling pathway

Recovery from acute pancreatitis (AP) involves complex biological processes, and the mechanisms governing pancreatic repair remain unclear. In a clinical cohort during the recovery phase of AP, impaired pancreatic recovery was associated with intestinal dysbiosis, depletion of the microbial bile ...

2026-03-08 | MTBLS14000 | MetaboLights
GenomicsREG3A promotes the development of pancreatic cancer by activating EGFR pathway
REG3A promotes the development of pancreatic cancer by activating EGFR pathway
PRJNA1190379 | ENA
TranscriptomicsREG3A promotes the development of pancreatic cancer by activating EGFR pathway
REG3A is highly expressed in pancreatic tissues, but its significance is unclear. We found that REG3A overexpressed in paracancerous acinar cells interacted with EGFR on tumor cells to stimulate downstream tumor growth signals and promote the occurrence and development of tumors
ORGANISM(S): Homo sapiens 
2025-02-26 | GSE282763 | GEO
UnknownAntimicrobial protein REG3A and signaling networks are predictive of stroke outcomes.
Not available
S-EPMC8716419 | biostudies-literature
TranscriptomicsTranscriptome study of colon epithelial cells in Reg3a-transgenic mice
The human C-type lectin Reg3a (HIP/PAP) is an antimicrobial peptide that kills Gram-positive bacteria. Reg3a preserves gut microbiota homeostasis, reinforces intestinal barrier function and thereby helps to fight induced colitis in mice. Transcriptomic data revealed an upregulation of numerous genes...
ORGANISM(S): Mus musculus 
2018-01-31 | GSE64932 | GEO
UnknownTumour-Derived Reg3A Educates Dendritic Cells to Promote Pancreatic Cancer Progression.
Not available
S-EPMC8490200 | biostudies-literature
UnknownHyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes.
Not available
S-EPMC5109591 | biostudies-literature
UnknownTumor-Stroma Crosstalk Enhances REG3A Expressions that Drive the Progression of Hepatocellular Carcinoma.
Not available
S-EPMC7013972 | biostudies-literature
UnknownAntimicrobial protein REG3A regulates glucose homeostasis and insulin resistance in obese diabetic mice.
Not available
S-EPMC10015038 | biostudies-literature
UnknownUp-regulation of REG3A in colorectal cancer cells confers proliferation and correlates with colorectal cancer risk.
Not available
S-EPMC4826180 | biostudies-literature
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