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ProteomicsFragmentation of mitochondrial mt-tRNA-LeuTAA provides a regulator of metabolic physiology
In this study, we discovered cytosolic and mitochondrial fragments resulting from tRNA and mt-tRNA cleavage, which may act as new regulators of cellular and metabolic functions. We selected the mt-tRF-LeuTAA fragment derived from a tRNA encoded by the mitochondrial genome for further investigation, ...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-06-16 | PXD046117 | Pride
Mitochondrial metabolism Trna-derived fragment Insulin secretion Insulin sensitivity Mitochondrial trna 
Proteomics5’tRNA-derived fragments modulate beta cell homeostasis and islet macrophage activation in type 2 diabetes – Mouse islets proteomics
During obesity and type 2 diabetes, pancreatic β-cells face chronic environmental stress, while islet-resident macrophages (iMACs) undergo metabolic reprogramming that exacerbates β-cell dysfunction. Stress-induced cleavage of tRNAs generates tRNA-derived fragments (tRFs), whose role in this context...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-12 | PXD065746 | Pride
Trna Macrophages Non-coding rnas Diabetes 
Proteomics5’tRNA-derived fragments modulate beta cell homeostasis and islet macrophage activation in type 2 diabetes - BMDM pull-down
During obesity and type 2 diabetes, pancreatic β-cells face chronic environmental stress, while islet-resident macrophages (iMACs) undergo metabolic reprogramming that exacerbates β-cell dysfunction. Stress-induced cleavage of tRNAs generates tRNA-derived fragments (tRFs), whose role in this context...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-12 | PXD065736 | Pride
Trna Macrophages Non-coding rnas Diabetes 
Proteomics5’tRNA-derived fragments modulate beta cell homeostasis and islet macrophage activation in type 2 diabetes - MIN6 pull-down
During obesity and type 2 diabetes, pancreatic β-cells face chronic environmental stress, while islet-resident macrophages (iMACs) undergo metabolic reprogramming that exacerbates β-cell dysfunction. Stress-induced cleavage of tRNAs generates tRNA-derived fragments (tRFs), whose role in this context...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-12 | PXD065726 | Pride
Trna Macrophages Non-coding rnas Diabetes 
Proteomics5’tRNA-derived fragments modulate beta-cell homeostasis and islet macrophage activation in type 2 diabetes
During obesity and type 2 diabetes, pancreatic β-cells face chronic environmental stress, while islet-resident macrophages (iMACs) undergo metabolic reprogramming that exacerbates β-cell dysfunction. Stress-induced cleavage of tRNAs generates tRNA-derived fragments (tRFs), whose role in this context...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-12 | PXD073702 | Pride
Trna fragments Diabetes Macrophages Rna-binding protein 
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