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GenomicsCell stage dependent transcriptional response to leukaemic oncogene expression
Acute myeloid leukemia (AML) is characterized by a block in myeloid differentiation the stage of which is dependent on the nature of the transforming oncogene and the developmental stage of the oncogenic hit. This is also true for the t(8;21) translocation which gives rise to the RUNX1/ETO fusion pr...
ORGANISM(S): Mus musculus 
2015-08-26 | E-GEOD-64589 | biostudies-arrayexpress
TranscriptomicsCell stage dependent transcriptional response to leukemic oncogene
Acute myeloid leukemia (AML) is characterized by a block in myeloid differentiation the stage of which is dependent on the nature of the transforming oncogene and the developmental stage of the oncogenic hit. This is also true for the t(8;21) translocation which gives rise to the RUNX1/ETO fusion pr...
ORGANISM(S): Mus musculus 
2015-08-26 | E-GEOD-64541 | biostudies-arrayexpress
TranscriptomicsActive and repressive chromatin in the mammalian genome intersperse without spreading in imprinted gene clusters
The Igf2r imprinted cluster is an epigenetic model of cis-acting silencing in which expression of a ncRNA silences multiple genes. Here, we map chromatin profiles on the maternal and paternal chromosome in a 250 kb region. We show that histone modifications associated with expressed and silent genes...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-5834 | biostudies-arrayexpress
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