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TranscriptomicsGene expression of murine B cells activated via TLR4 or TLR4 + CD40: Group1 naM-CM-/ve B cells, Group2 LPS activated B cells 24h, Group3 LPS + anti-CD40 activated B cells 24h, Group4 LPS activated B cells 72h, and Group5 LPS + anti-CD40 activated B cells 72h.
Murine B cells can be activated via the surface receptors TLR4 and CD40. For a global assessment of differences in gene expression between these two different modes of B cell activation a genome wide transcriptome analysis was performed. In order to dissect different gene expression profiles of B ce...
ORGANISM(S): Mus musculus 
2014-02-24 | E-GEOD-35998 | biostudies-arrayexpress
TranscriptomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [RNA-Seq]
Down syndrome (DS) confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (ALL), yet the mechanisms underlying this association are undefined.  We show that triplication of only 31 genes orthologous to the putative DS Critical Region (DSCR) on chr.21q22 is sufficient to promote B ce...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48553 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation profiling of CD4+ T cells and CD19+ B cells in autoimmune-disease associated HLA class II genotype carriers (HLA-DR2-DQ6, -DR3-DQ2 and -DR4-DQ8 homozygotes) using Illumina Infinium HumanMethylation EPIC beadchip
The Human leukocyte antigen (HLA) -region, especially HLA class I and II genes, plays a major role in the predisposition to autoimmune disorders. Particularly three HLA haplotypes, DRB1*03-DQA1*05-DQB1*02 (DR3-DQ2), DRB1*04:01-DQA1*03-DQB1*03:02 (DR4-DQ8) and DRB1*15-DQA1*01-DQB1*06:02 (DR2-DQ6), ha...
ORGANISM(S): Homo sapiens 
2024-06-20 | E-MTAB-13654 | biostudies-arrayexpress
UnknownBody mass index is associated with risk of reoperation and revision after primary total hip arthroplasty: a study of the Swedish Hip Arthroplasty Register including 83,146 patients.
Not available
S-EPMC6534237 | biostudies-literature
UnknownAutoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes.
Not available
S-EPMC4205657 | biostudies-literature
UnknownIncreased early mortality and morbidity after total hip arthroplasty in patients with socioeconomic disadvantage: a report from the Swedish Hip Arthroplasty Register.
Not available
S-EPMC6534205 | biostudies-literature
UnknownARNT PAS-B has a fragile native state structure with an alternative beta-sheet register nearby in sequence space.
Not available
S-EPMC2650313 | biostudies-literature
UnknownDual mobility cups in primary total hip arthroplasties: trend over time in use, patient characteristics, and mid-term revision in 3,038 cases in the Dutch Arthroplasty Register (2007-2016).
Not available
S-EPMC6366470 | biostudies-literature
UnknownAssociation between patient survival following reoperation after total hip replacement and the reason for reoperation: an analysis of 9,926 patients in the Swedish Hip Arthroplasty Register.
Not available
S-EPMC6534231 | biostudies-literature
UnknownPsychotropic medication use pre and post-diagnosis of cluster B personality disorder: a Quebec's health services register cohort.
Not available
S-EPMC10702219 | biostudies-literature
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