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Regulatory Mechanisms of Atrial Remodeling of Mitral Regurgitation Pigs This study enrolled 6 pigs (age: 18 months) and divided into three groups: mitral regurgitation pigs (MR) (n = 2; 2 males sacrificed 12 months after surgery), MR pigs treated with valsartan (MRV) (n = 2; 2 males age-matched to ...
ORGANISM(S): Sus scrofa 
Compared Gene Expression Profiling of Rats with Aortic valve Regurgitation (AR) vs Sham operated Rats
ORGANISM(S): Rattus norvegicus 
Aortic valve regurgitation (AR) imposes a severe volume overload to the left ventricle (LV) which results in dilation, eccentric hypertrophy and eventually loss of function. Little is known about the impact of AR on LV gene expression. We therefore conducted a gene expression profiling study in the ...
ORGANISM(S): Rattus norvegicus 
Transcriptomic analysis of cardiac remodelling following minimally invasive surgery for aortic regurgitation
Transcriptomic analysis of mouse heart after a minimally invasive mitral regurgitation surgery (MiMRS)
To explore the signaling pathways involved in aortic regurgitation (AR)-induced dysregulation from the compensated phase of the heart to the heart failure phase, and to discover the characteristic genes closely related to AR.
ORGANISM(S): Mus musculus 
2025-11-18 | GSE252164 | GEO
Mitral valve was damaged to cause regurgitation induced by a novel and minimally invasive surgery in mice, and hearts were collected for high-throughput sequencing at week 2 (compensatory) after surgery.
ORGANISM(S): Mus musculus 
2025-10-27 | GSE271640 | GEO
Regulatory Mechanisms of Atrial Remodeling of Human Mitral Regurgitation
ORGANISM(S): Homo sapiens 
2016-11-07 | GSE63045 | GEO
Single-cell analysis reveals the loss of progenitor subpopulation of valvular endothelial cells leads to functional mitral regurgitation
Background: Following myocardial infarction, mitral regurgitation (MR) is a common complication. Previous animal studies demonstrated the association of endothelial-to-mesenchymal transition (EndMT) with mitral valve (MV) remodeling. Nevertheless, little is known about how MV tissue responds to isch...
ORGANISM(S): Homo sapiens (Human) 
2021-08-13 | PXD025096 | Pride
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