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TranscriptomicsSingle-cell profiling of ectopic velvet grafts transplanted onto non-regenerative backskin to assess whether regenerative propensity is intrinsic to reindeer velvet
We have previously described the reindeer antler velvet as a highly unique mammalian model of adult skin regeneration as wounds on backskin form a raised, contractile scar devoid of appendages or pigment, whereas identical wounds in antler velvet exhibit scar-less regeneration. To ask whether regene...
ORGANISM(S): Rangifer tarandus 
2022-12-08 | GSE153095 | GEO
TranscriptomicsscRNA-Seq datasets profiling peripheral leukocyte response when co-cultured with fibroblasts isolated from reindeer back skin or antler velvet.
In adult mammals, skin wound healing has evolved to favor rapid repair through the formation of fibrotic scar. These dermal scars are dysfunctional and may lead to chronic disfigurement and disability, yet the biologic mechanisms that drive fibrosis and prevent tissue regeneration remain unknown. He...
ORGANISM(S): Rangifer tarandus 
2022-12-08 | GSE207021 | GEO
ProteomicsSkin regeneration is enabled in the absence of fibroblast inflammatory priming
Mammalian skin wounds heal by forming fibrotic scars. We report that reindeer antler velvet exhibits regenerative wound healing, whereas identical injury to back skin forms scar. This regenerative capacity was retained following ectopic transplantation of velvet to scar-forming sites. Single-cell mR...
ORGANISM(S): Homo sapiens (Human) 
2023-02-23 | PXD035749 | Pride
Reindeer antler velvet  wound healing  skin regeneration  stromal-immune crosstalk  immune modulation  inflammatory-priming  fibrotic scar  fetal human fibroblasts  myeloid cell maturation  single-cell multi-omics 
TranscriptomicsSingle-cell RNA-Seq datasets profiling PBMCs from venous blood supply to antler velvet or to backskin 3 days post-wound
Project abstract: In adult mammals, skin wound healing has evolved to favor rapid repair through the formation of fibrotic scar. These dermal scars are dysfunctional and may lead to chronic disfigurement and disability, yet the biologic mechanisms that drive fibrosis and prevent tissue regeneration ...
ORGANISM(S): Rangifer tarandus 
2022-12-08 | GSE180653 | GEO
GenomicsscRNA-Seq datasets profiling peripheral leukocyte response when co-cultured with fibroblasts isolated from reindeer back skin or antler velvet.
scRNA-Seq datasets profiling peripheral leukocyte response when co-cultured with fibroblasts isolated from reindeer back skin or antler velvet.
PRJNA853330 | ENA
GenomicsSingle-cell profiling of ectopic velvet grafts transplanted onto non-regenerative backskin to assess whether regenerative propensity is intrinsic to reindeer velvet
Single-cell profiling of ectopic velvet grafts transplanted onto non-regenerative backskin to assess whether regenerative propensity is intrinsic to reindeer velvet
PRJNA641419 | ENA
GenomicsSingle-cell chromatin landscapes supporting fibroblast polarization drives skin regeneration versus fibrosis in adult reindeer
In adult mammals, skin wound healing has evolved to favor rapid repair through the formation of fibrotic scar. These dermal scars are dysfunctional and may lead to chronic disfigurement and disability, yet the biologic mechanisms that drive fibrosis and prevent tissue regeneration remain unknown. He...
ORGANISM(S): Rangifer tarandus 
2022-12-08 | GSE176360 | GEO
TranscriptomicsBulk RNA-Seq datasets supporting fibroblast polarization drives skin regeneration versus fibrosis in adult reindeer
In adult mammals, skin wound healing has evolved to favor rapid repair through formation of fibrotic scar. Consequently, skin wounds are dysfunctional and lead to chronic disfigurement and disability, yet the biologic mechanisms that drive fibrosis and prevent tissue regeneration remain unknown. Her...
ORGANISM(S): Rangifer tarandus 
2022-12-08 | GSE168746 | GEO
TranscriptomicsSingle-cell RNA-Seq datasets supporting fibroblast polarization drives skin regeneration versus fibrosis in adult reindeer
In adult mammals, skin wound healing has evolved to favor rapid repair through the formation of fibrotic scar. These dermal scars are dysfunctional and may lead to chronic disfigurement and disability, yet the biologic mechanisms that drive fibrosis and prevent tissue regeneration remain unknown. He...
ORGANISM(S): Rangifer tarandus 
2022-12-08 | GSE142854 | GEO
UnknownFibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer.
Not available
S-EPMC9888357 | biostudies-literature
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