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TranscriptomicsGenome-wide analysis of germ cell proliferation in C. elegans
Proliferating germ cells in C. elegans provide a useful model system for deciphering fundamental mechanisms underlying the balance between proliferation and differentiation. Using gene expression profiling of mutants with excess germ cell proliferation, we identified approximately 200 genes express...
ORGANISM(S): Caenorhabditis elegans 
2010-04-29 | E-GEOD-21531 | biostudies-arrayexpress
TranscriptomicsPromotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1(E2F)does not require LIN-35(pRB)
Microarray-based expression profiling of dissected gonads from efl-1, dpl-1 and lin-35 mutants reveals that EFL-1 and DPL-1 promote expression of an extensively overlapping set of target genes, consistent with the expectation that these two proteins function as a heterodimer. Regulatory regions ups...
ORGANISM(S): Caenorhabditis elegans 
2010-07-01 | E-GEOD-5071 | biostudies-arrayexpress
TranscriptomicsGene expression in germ line
Identification of genes expressed in the germ line of C. elegans. This SuperSeries is composed of the following subsets: Direct comparison of fem-3(gf) vs fem-1(lf): GSE725: oocytes vs sperm Indirect comparisons between males and hermaphrodites with and without a germline: GSE715: glp-4 adults GS...
ORGANISM(S): Caenorhabditis elegans 
2010-05-27 | E-GEOD-696 | biostudies-arrayexpress
TranscriptomicsExpression Profiling of MAP Kinase-Mediated Meiotic Progression in C. elegans
A unique allele of MAP kinase, mpk-1(ga111), displays a reversible, temperature-sensitive, tissue-specific defect in progression through meiotic prophase I. We performed gene expression profiling on mpk-1(ga111) animals at multiple times after shift to permissive temperature to identify candidate d...
ORGANISM(S): Caenorhabditis elegans 
2010-07-01 | E-GEOD-5069 | biostudies-arrayexpress
TranscriptomicsMES-4, an autosome-associated HMT that participates in silencing the X chromosomes in the C. elegans germ line
Microarray-based expression profiling of dissected gonads from mes-4 mutants reveals that MES-4 is required to repress expression of a set of X-linked genes. We isolated dissected gonads from mes-4(bn85) mutant adults and compared to dissected gonads from wild type (N2 animals. RNA was linearly amp...
ORGANISM(S): Caenorhabditis elegans 
2010-07-01 | E-GEOD-5454 | biostudies-arrayexpress
TranscriptomicsDEPS-1 promotes P granule assembly and RNA interference in C. elegans germ cells
P granules are germ-cell-specific cytoplasmic structures containing RNA and protein and required for proper germ cell development in C. elegans. A new P-granule-associated protein, DEPS-1, whose loss disrupts P granule structure and function was analysed in this study. Genome wide analysis of gene...
ORGANISM(S): Caenorhabditis elegans 
2010-05-26 | E-GEOD-9993 | biostudies-arrayexpress
TranscriptomicsA C. elegans LSD1 Demethylase Contributes to Germline Immortality by Reprogramming Epigenetic Memory
Microarray-based expression profiling of mixed stage populations taken from generation 1,13 and 26 spr-5 mutant animals as well as wild-type animals reveals a large class of spermatogenesis-expressed genes whose expression coordinately increased from generations 1 to 13 and then decreased from gener...
ORGANISM(S): Caenorhabditis elegans 
2010-06-19 | E-GEOD-14432 | biostudies-arrayexpress
Transcriptomicsgonad-only_young_adult_20dC_42hrs_post-L1_N2_tiling_array
modENCODE_submission_481 This submission comes from a modENCODE project of Robert Waterston. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: Our experiments are designed to detect all C. elegans transcripts by hybridizing RNA to commerically available genome til...
ORGANISM(S): Caenorhabditis elegans 
2010-08-04 | E-GEOD-23269 | biostudies-arrayexpress
GenomicsIdentification of Transcription Factor ALR-1::GFP Binding Regions in L2
modENCODE_submission_3156 This submission comes from a modENCODE project of Michael Snyder. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We are identifying the DNA binding sites for 300 transcription factors in C. elegans. Each transcription factor gene is ta...
ORGANISM(S): Caenorhabditis elegans 
2011-03-31 | E-GEOD-25787 | biostudies-arrayexpress
GenomicsIdentification of Transcription Factor PHA-4::GFP Binding Regions in L2
modENCODE_submission_3158 This submission comes from a modENCODE project of Michael Snyder. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We are identifying the DNA binding sites for 300 transcription factors in C. elegans. Each transcription factor gene is ta...
ORGANISM(S): Caenorhabditis elegans 
2011-03-31 | E-GEOD-26153 | biostudies-arrayexpress
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