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ProteomicsDNGR-1/CLEC9A signaling limits cDC1 activation to optimize crosspresentation of dead cell antigens
Innate immune receptors induce activation of conventional dendritic cells (cDCs) and enhance antigen (cross-)presentation, favoring immune responses. DNGR-1 (CLEC9A), a receptor expressed by type 1 cDCs (cDC1s) and implicated in immunity to viruses and cancers, recognizes F-actin exposed on dead cel...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-28 | PXD059637 | Pride
Mouse Dendritic cell Lc-ms/ms Innate immune receptor 
UnknownOncogenic Transformation of Dendritic Cells and Their Precursors Leads to Rapid Cancer Development in Mice.
Not available
S-EPMC4635568 | biostudies-literature
TranscriptomicsExpression data from Flt3L-derived bone marrow dendritic cells from WT or Clec9agfp/gfp mice treated or not with dead cells
DNGR-1 (CLEC9A) is expressed in CD8-like dendritic cells (DCs) and detects a ligand exposed on necrotic cells. We have characterized the transcripts that are induced in cultures of Flt3L-derived bone-marrow-derived WT or DNGR1-deficient DCs upon incubation with dead cells. Microarray analysis of the...
ORGANISM(S): Mus musculus 
2012-04-30 | E-GEOD-36435 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of different sub-types of mouse dendritic cells to study the functional relationships and properties of these cells.
The functional relationships and properties of different sub-types of dendritic cells (DC) remain largely undefined. We used a global gene profiling approach to determine gene expression patterns among murine splenic CD11c high DC subsets in an effort to better characterise these cells.
ORGANISM(S): Mus musculus 
2007-09-11 | E-GEOD-339 | biostudies-arrayexpress
UnknownAltered lymph node composition in diphtheria toxin receptor-based mouse models to ablate dendritic cells.
Not available
S-EPMC4272857 | biostudies-literature
UnknownInactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells.
Not available
S-EPMC5167344 | biostudies-literature
UnknownThe RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells.
Not available
S-EPMC5813259 | biostudies-literature
UnknownCyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.
Not available
S-EPMC4597191 | biostudies-literature
UnknownAn isoform of Dicer protects mammalian stem cells against multiple RNA viruses.
Not available
S-EPMC7611482 | biostudies-literature
UnknownDendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors.
Not available
S-EPMC5529209 | biostudies-literature
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