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TranscriptomicsZfx controls BCR-induced proliferation and survival of B lymphocytes
The development, homeostasis and function of B lymphocytes involve multiple rounds of B cell receptor (BCR)-controlled proliferation and prolonged maintenance. We analyzed the role of transcription factor Zfx, a recently identified regulator of stem cell maintenance, in B cell development and homeos...
ORGANISM(S): Mus musculus 
2009-04-16 | E-GEOD-13547 | biostudies-arrayexpress
GenomicsMus musculus
Zfx controls BCR-induced proliferation and survival of B lymphocytes
PRJNA110725 | ENA
GenomicsMtg16 regulates E protein activity and lineage specification in dendritic cell development (ChIP-seq)
E protein transcription factors specify major immune cell lineages including lymphocytes and interferon-producing plasmacytoid dendritic cells (pDCs). Corepressors of the ETO family can bind to and block transactivation by E proteins, but the physiological role of these interactions remained unclear...
ORGANISM(S): Homo sapiens 
2014-06-13 | E-GEOD-43876 | biostudies-arrayexpress
TranscriptomicsNotch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine
Dendritic cells (DCs) in tissues and lymphoid organs comprise distinct functional subsets that differentiate in situ from circulating progenitors. Tissue-specific signals that regulate DC subset differentiation are poorly understood. We report that DC-specific deletion of the Notch2 receptor caused ...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-31551 | biostudies-arrayexpress
TranscriptomicsThe Cellular and Molecular Origin of Tumor-associated Macrophages
Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and immune defense against pathogens, macrophages are being rediscovered as regulators of several diseases including cancer. Here we show that in mice, mammary tumor growth induces the accumulation of tumor-associ...
ORGANISM(S): Mus musculus 
2014-04-18 | E-GEOD-56755 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse splenic Dendritic cells subsets
We describe a novel subset of CD8+ DCs in lymphoid organs of naïve mice characterized by expression of the CX3CR1 chemokine receptor. CX3CR1+CD8+ DCs lack hallmarks of classical CD8+ DCs, including IL12 secretion, the capacity to cross-present antigen and their developmental independence of the tran...
ORGANISM(S): Mus musculus 
2010-07-28 | E-GEOD-23212 | biostudies-arrayexpress
TranscriptomicsContinuous expression of the transcription factor E2-2 maintains the cell fate of mature plasmacytoid dendritic cells
This SuperSeries is composed of the following subset Series: GSE24726: Gene expression profile of mature plasmacytoid dendritic cells (PDC) after the deletion of transcription factor E2-2 GSE24740: Binding targets of transcription factor E2-2 in human plasmacytoid dendritic cells Refer to individual...
ORGANISM(S): Homo sapiens 
2010-12-21 | E-GEOD-24785 | biostudies-arrayexpress
TranscriptomicsEffect of genetic Zfx deletion on Myc induced gene expression in bone marrrow myeloid progenitors
Acute myeloid leukemia (AML) and acute T-lymphoblastic leukemia (T-ALL) maintain the undifferentiated phenotype and proliferative capacity of their respective cells of origin, hematopoietic stem/progenitor cells and immature thymocytes. The mechanisms that maintain these progenitor-like characterist...
ORGANISM(S): Mus musculus 
2014-01-30 | E-GEOD-52416 | biostudies-arrayexpress
TranscriptomicsEffect of genetic Zfx deletion on gene expression in c-Kit + MLL-AF9 AML cells
Acute myeloid leukemia (AML) propagates as a cellular hierarchy which is maintained by a rare subpopulation of self-renewing leukemia-initiating cells (LICs). These LICs phenotypically resemble HSCs and early myeloid progenitors, and they are functionally defined by their ability to reconstitute AML...
ORGANISM(S): Mus musculus 
2014-01-30 | E-GEOD-36921 | biostudies-arrayexpress
TranscriptomicsMtg16 regulates E protein activity and lineage specification in dendritic cell development (gene expression)
E protein transcription factors specify major immune cell lineages including lymphocytes and interferon-producing plasmacytoid dendritic cells (pDCs). Corepressors of the ETO family can bind to and block transactivation by E proteins, but the physiological role of these interactions remained unclear...
ORGANISM(S): Mus musculus 
2014-06-13 | E-GEOD-43874 | biostudies-arrayexpress
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