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TranscriptomicsTranscription profiling of male rats Brown Norway and F344 reveals coordinated changes in xenobiotic metabolizing enzyme gene expression in aging
In order to gain insight into the effects of aging on susceptibility to environmental toxins, we characterized the expression of xenobiotic metabolizing enzymes (XMEs) from the livers of male Brown Norway and F344 rats across the adult lifespan. To examine metabolic processes across lifespan after c...
ORGANISM(S): Rattus norvegicus 
2008-10-20 | E-GEOD-11097 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild-type and PPARalpha-null mutants response to PFOA
Toxicogenomic Dissection of the Perfluorooctanoic Acid (PFOA) Transcript Profile in Mouse Liver: Evidence for the Involvement of Nuclear Receptors PPARalpha and CAR; We performed a toxicogenomics dissection of the transcript profiles in the mouse liver after exposure to PFOA. We uncovered classes o...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9786 | biostudies-arrayexpress
TranscriptomicsHepatic xenobiotic metabolizing enzyme gene expression through the life stages of the mouse
Using full-genome arrays, the expression of all XMEs was examined during fetal (gestation day (GD) 19), neonatal (postnatal day (PND) 7), prepubescent (PND30), middle age (12 mon), and old age (18 and 24 mon) in the C57Bl6/J mouse liver and compared to young adults. Fetal and neonatal life stages h...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-21716 | biostudies-arrayexpress
TranscriptomicsTranscriptional ontogeny of the developing liver
We characterized gene expression changes in the developing mouse liver at gestational days (GD) 11.5, 12.5, 13.5, 14.5, 16.5, and 19.5 and in the neonate (postnatal day (PND) 7 and 30) using full-genome microarrays and compared these changes to that in the adult liver. The fetal liver, and to a less...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-21224 | biostudies-arrayexpress
TranscriptomicsTumorigenic carryover effects of early life exposure to dichloroacetic acid in male B6C3F1 mice
Here we investigated the longterm carryover effects of dichloroacetic acid (DCA), a common by-product of drinking water chlorination, on hepatic tumorigenesis in mice. Our findings demonstrate that postnatal exposure to a common drinking water contaminant results in longterm carryover effects on tum...
ORGANISM(S): Mus musculus 
2015-02-26 | E-GEOD-58585 | biostudies-arrayexpress
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