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MetabolomicsMetabolic characterization of directly reprogrammed renal tubular epithelial cells (iRECs)
Fibroblasts can be directly reprogrammed to induced renal tubular epithelial cells (iRECs) using four transcription factors. These engineered cells may be used for disease modeling, cell replacement therapy or drug and toxicity testing. Direct reprogramming induces drastic changes in the transcripti...
2021-08-20 | MTBLS608 | MetaboLights
TranscriptomicsHuman iPSC-based Modeling of Late-Onset Disease using Progerin-induced Aging
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) sets their identity back to an embryonic age. This presents a fundamental hurdle for modeling late-onset disorders using iPSC-derived cells. We therefore developed a strategy to induce age-like features in multiple iPSC-derived li...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-52431 | biostudies-arrayexpress
TranscriptomicsGene expression in post cardiac surgery acute kidney injury
To determine the changes in intra-renal gene expression in a novel large animal model of post Cardiopulmonary Bypass (CPB) acute kidney injury, we collected renal medulla samples obtained 24hours post intervention. The transcriptional profile of the mRNA in these samples was measured with gene array...
ORGANISM(S): Sus scrofa 
2014-09-29 | E-GEOD-44782 | biostudies-arrayexpress
TranscriptomicsModeling Familial Cancer with iPSC Approaches
In vitro modeling of human disease has recently become feasible with the adoption of induced pluripotent stem cell (iPSC) technology. Here, we established patient-derived iPSCs from an Li-Fraumeni Syndrome (LFS) family and investigated the role of mutant p53 in the development of osteosarcoma (OS). ...
ORGANISM(S): Homo sapiens 
2015-04-10 | E-GEOD-58123 | biostudies-arrayexpress
TranscriptomicsGene expression changes during resistance toward vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI) therapy in renal cell carcinoma (RCC)
This study was performed to understand the gene expression changes that accompany treatment of renal cell carcinoma (RCC) with vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI) therapy. Human RCC cell lines were implanted into the flanks of nude beige mice, allowed...
ORGANISM(S): Homo sapiens 
2015-05-21 | E-GEOD-64052 | biostudies-arrayexpress
MetabolomicsTubular insulin-induced gene 1 deficiency promotes NAD+ consumption and exacerbates kidney fibrosis

Profibrotic proximal tubular (PT) were identified as a unique phenotype of PTCs in renal fibrosis by single-cell RNA sequencing (scRNA-seq). Controlling the process of renal fibrosis requires understanding how to manage the S1 subset's branch to the S3 subset rather than to the profibrotic PT sub...

2024-05-28 | MTBLS9985 | MetaboLights
TranscriptomicsIGR_VHL_GE
VHL is a tumor suppressor gene involved in the oxygen-sensing pathway whose germline mutations predispose to distinct phenotypes. Heterozygous mutations predispose to von Hippel-Lindau disease characterized by the development of multiple tumors (including hemangioblastomas, renal cell carcinomas and...
ORGANISM(S): Homo sapiens 
2013-09-03 | E-MTAB-1269 | biostudies-arrayexpress
TranscriptomicsFunctional and Transcriptomic Characterization of iPSC-derived Macrophages and their Application in Modeling Mendelian Disease
Using RNA-Seq, we reported novel findings in the comparison of transcriptome profiles of isogenic HMDM and IPSDM during differentiation and polarization. First, IPSDM lost expression of pluripotency markers, had remarkably distinct gene expression profiles relative to precursor iPSCs, and had largel...
ORGANISM(S): Homo sapiens 
2015-07-08 | E-GEOD-55536 | biostudies-arrayexpress
MetabolomicsDNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease (CKD). Herein, we found that the expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) was significantly increased in the kidney tissues of both CKD...

2023-01-25 | MTBLS5971 | MetaboLights
no omics definedTranscription profiling of yeast with a fumarase point mutation or knock-out to model hereditary leiomyomatosis and renal cell cancer
Effect of fumarase point mutation or knock-out on transcriptional profile in yeast to model hereditary leiomyomatosis and renal cell cancer (HLRCC).
ORGANISM(S): Saccharomyces cerevisiae 
2006-11-29 | E-MEXP-922 | biostudies-arrayexpress
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