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MetabolomicsSterol-O acyltransferase inhibition ameliorates high-fat diet-induced renal fibrosis and tertiary lymphoid tissue maturation after ischemic reperfusion injury (Mice+injury analysis)

Metabolic syndrome is a growing global health problem and is strongly associated with the development of chronic kidney disease (CKD). Recently, the prevalence of CKD has been increasing worldwide, particularly among the older adults. We previously demonstrated that aged kidneys are prone to deve...

2022-12-05 | MTBLS4988 | MetaboLights
MetabolomicsSterol-O acyltransferase inhibition ameliorates high-fat diet-induced renal fibrosis and tertiary lymphoid tissue maturation after ischemic reperfusion injury (Mice+diet analysis)

Metabolic syndrome is a growing global health problem and is strongly associated with the development of chronic kidney disease (CKD). Recently, the prevalence of CKD has been increasing worldwide, particularly among the older adults. We previously demonstrated that aged kidneys are prone to deve...

2022-12-05 | MTBLS4994 | MetaboLights
Transcriptomicssmall RNA-Seq of rat kidney in a model of ischemic preconditioning/ischemia-reperfusion injury
Ischemic preconditioning is effective in limiting subsequent ischemic acute kidney injury in experimental models. microRNAs are an important class of post-transcriptional regulator and show promise as biomarkers of kidney injury. An evaluation was performed of the time- and dose-dependent effects o...
ORGANISM(S): Rattus norvegicus 
2021-12-31 | E-MTAB-9896 | biostudies-arrayexpress
TranscriptomicsRNA microarray of rat kidney treated with or without silicon nano-particles against ischemia reperfusion injury
RNA microarray was performed to evaluate the efficacy of silicon nano-particles on renal transcriptomes of rats against ischemia reperfusion injury. We compared the transcriptomes of ischemia reperfusion injury model rats with or without oral administration of silicon nano-particles. We also tried t...
ORGANISM(S): Rattus norvegicus 
2020-02-04 | E-MTAB-8687 | biostudies-arrayexpress
TranscriptomicsExiqon miRCURY microRNA array of rat kidney in a model of ischemic preconditioning/ischemia-reperfusion injury
Ischemic preconditioning is effective in limiting subsequent ischemic acute kidney injury in experimental models. microRNAs are an important class of post-transcriptional regulator and show promise as biomarkers of kidney injury. An evaluation was performed of the time- and dose-dependent effects o...
ORGANISM(S): Rattus norvegicus 
2021-12-31 | E-MTAB-9900 | biostudies-arrayexpress
MetabolomicsCXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
Kidney injury is a common complication of severe disease. Here, we report that injuries of the zebrafish embryonal kidney are rapidly repaired by a migratory response in 2-, but not in 1-day-old embryos. Gene expression profiles between these two developmental stages identify cxcl12a and myca as can...
2018-10-11 | MTBLS723 | MetaboLights
TranscriptomicsTranscription profiling of mouse lung to investigate effects of ischemia reperfusion injury or nephrectomy
Experiments in rodents have shown that kidney ischemia/reperfusion injury (IRI) facilitates lung injury and inflammation. To identify potential ischemia-specific lung molecular pathways involved, we conducted global gene expression profiling of lung 6 or 36 hours following 1) bilateral kidney IRI, 2...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6730 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in rat renal allografts after prolonged cold ischemia
Ischemia/reperfusion injury (IRI) has a major impact on the long-term outcome of renal allografts. However, the mechanisms of IRI related to chronic allograft nephropathy (CAN) are still poorly understood. To address this issue, in a F344 to Lewis transplantation model of the rat, kidneys were eithe...
ORGANISM(S): Rattus norvegicus 
2010-06-25 | E-GEOD-4441 | biostudies-arrayexpress
TranscriptomicsTolerogenic dendritic cells protect against acute kidney injury
We use tolDCs from syngeneic (C57BL6) and allogeneic (BALB/c) mice to show potent renoprotective abilities in a ischemia reperfusion AKI model. Dendritic cells were derived from mice bone marrow and cultured for 7 days with GM-CSF and IL-4. Tolerogenic DCs were cultured in the same DC media but with...
ORGANISM(S): Mus musculus 
2024-11-25 | E-MTAB-14618 | biostudies-arrayexpress
TranscriptomicsAcute cellular injury responses in mouse renal ischemic reperfusion injury
Acute kidney injury (AKI) is associated with an abrupt loss of kidney function that results in significant morbidity and mortality. Considerable effort has focused around the identification of diagnostic biomarkers and the analysis of molecular events. Most studies have adopted organ-wide approaches...
ORGANISM(S): Mus musculus 
2014-03-06 | E-GEOD-52004 | biostudies-arrayexpress
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