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MetabolomicsThe accumulation of methylglyoxal and acrolein leads to arginine depletion causing hyperglycemia and renal abnormalities

There is growing evidence to support the idea that the accumulation of reactive carbonyl species plays a significant causal role in the pathogenesis of ageing, cardiovascular diseases, diabetes and its complications. Among reactive carbonyl species, methylglyoxal and acrolein, detoxified by glyox...

2026-06-17 | MTBLS14089 | MetaboLights
TranscriptomicsRenal Cell Carcinoma
Renal cell carcinoma comprises several histological types with different clinical behavior. Accurate pathological characterization is important in the clinical management of these tumors. We describe gene expression profiles in 41 renal tumors determined by using DNA microarrays containing 22,648 un...
ORGANISM(S): Homo sapiens 
2006-01-31 | E-GEOD-4125 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of renal cancer from the Cancer Genomics of the Kidney (CAGEKID) project
The incidence of renal cell carcinoma (RCC) is increasing worldwide, and its prevalence is particularly high in some parts of Central Europe. The study describes transcriptome sequencing of clear cell RCC (ccRCC), the most common form of the disease, in patients from four different European countri...
ORGANISM(S): Homo sapiens 
2014-10-29 | E-MTAB-3033 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human kidney samples to discover gene signatures of progression and metastasis in renal cell cancer
In order to address the progression, metastasis, and clinical heterogeneity of renal cell cancer (RCC), transcriptional profiling with oligonucleotide microarrays (22,283 genes) was done on 49 RCC tumors, 20 non-RCC renal tumors, and 23 normal kidney samples. Samples were clustered based on gene exp...
ORGANISM(S): Homo sapiens 
2009-04-28 | E-GEOD-15641 | biostudies-arrayexpress
TranscriptomicsCCSK
Clear cell sarcoma of the kidney (CCSK), the second most common renal tumor in children, poses significant diagnostic challenges. No diagnostic positive markers are available, and the pathogenesis of CCSK remains an enigma. To address these challenges, the gene expression patterns of fourteen CCSK...
ORGANISM(S): Homo sapiens 
2005-09-22 | E-GEOD-2712 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of 19 renal cell carcinoma samples from patients with end-stage renal disease
In this study, 19 tumor samples from patients with renal cell carcinoma (RCC)-end-stage renal disease (ESRD) were analyzed by array comparative genomic hybridization (array CGH) using the Agilent Whole Human Genome 4× Array. 19 cystic disease samples from patients with RCC-ESRD
ORGANISM(S): Homo sapiens 
2012-04-01 | E-GEOD-33117 | biostudies-arrayexpress
TranscriptomicsExpression data from renal cysts of autosomal dominant polycystic kidney disease (ADPKD) patients
To elucidate the molecular pathways that modulate renal cyst growth in autosomal dominant polycystic kidney disease (ADPKD) Keywords: Disease state analysis We performed global gene profiling on renal cysts of different size (small cysts: less than 1 ml, n=5; medium cysts: between 10-25 ml, n=5; lar...
ORGANISM(S): Homo sapiens 
2009-08-14 | E-GEOD-7869 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of clear cell renal carcinomas and normal kidney cortical tissues
We performed a differential gene expression analysis comparing a collection of clear cell renal carcinoma tissue samples to normal cortical tissues. The Affymetrix GeneChip HG-U133 Plus 2.0 arrays were used.
ORGANISM(S): Homo sapiens 
2008-01-16 | E-TABM-282 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human papillary renal cell carcinoma to identify molecular PRCC subclasses with morphologic correlation
BACKGROUND: Despite the moderate incidence of papillary renal cell carcinoma; (PRCC), there is a disproportionately limited understanding of its underlying genetic programs. There is no effective therapy for metastatic PRCC, and patients are often excluded from kidney cancer trials. A morphological ...
ORGANISM(S): Homo sapiens 
2007-10-20 | E-GEOD-2748 | biostudies-arrayexpress
TranscriptomicsGene array analysis of clear cell renal cell carcinoma tissue versus matched normal kidney tissue
Currently there is a lack of effective therapies which result in long-term durable response for patients presenting with advanced and metastatic clear cell renal cell carcinoma (ccRCC). This is due in part to a lack of molecular factors which can be targeted pharmacologically. In order to identify n...
ORGANISM(S): Homo sapiens 
2014-01-03 | E-GEOD-53757 | biostudies-arrayexpress
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