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TranscriptomicsSox2 ablation in the DP alters its gene expression signature
Using Tbx18Cre to target embryonic DP precursors, we ablate Sox2 early and efficiently, resulting in diminished hair shaft outgrowth. Transcriptional profiling of Sox2 null DPs reveals increased Bmp6 and decreased Bmp inhibitor Sostdc1, a direct Sox2 transcriptional target. FACS sort to isolate Sox2...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-41597 | biostudies-arrayexpress
GenomicsWdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network
The embryonic stem (ES) cell transcriptional and epigenetic networks are critical for the maintenance of ES cell self-renewal. However, it remains unclear whether components of these networks functionally interact and if so, what factors mediate such interactions. Here we show that WD-repeat protein...
ORGANISM(S): Mus musculus 
2011-04-08 | E-GEOD-22934 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse immature pDC and pDC activated with CpG 1826 and influenza virus PR8
CpG 1826 binds to Toll-like receptor (TLR)9, whereas influenza virus PR8 activates pDC via TLR7. Differential stimulation of pDCs is expected to result in unique activation mechanism(s) leading to a different phenotypically and functionally matured pDC; We used microarrays to detail the global progr...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7831 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of embryonic skin development (developmental time series in full-thickness dorsal skin of mouse embryos)
In this study, we analysed early embryonic skin development (mus musculus; C57BL/6J) at the transcriptional level. Major questions concerned the cell type composition of early embryonic skin, and the emergence of transcriptional heterogeneity among epithelial and stromal precursor cells. Cells were ...
ORGANISM(S): Mus musculus 
2023-07-16 | E-MTAB-11920 | biostudies-arrayexpress
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