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TranscriptomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [RNA-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. RNA-Seq in primary adult human erythroid cells treated with UNC0638 or the vehicle control (DMSO) in biological triplicates.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71421 | biostudies-arrayexpress
GenomicsRenneville et al. Blood Cancer Discovery 2021
Avadomide induces degradation of ZMYM2 fusion oncoproteins in hematologic malignancies
PRJEB43161 | ENA
ProteomicsAvadomide induces degradation of ZMYM2 fusion oncoproteins in hematologic malignancies
Renneville A, Gasser JA, Grinshpun DE , Jean Beltran PM, Udeshi ND, Dr. Mary E. Matyskiela , Clayton T, McConkey M, Viswanathan K, Tepper A, Guirguis AA, Sellar RS, Cotteret S, Marzac C, Saada V, de Botton S, Kiladjian J, Cayuela J, Rolfe M, Chamberlain PP, Carr SA, Ebert BL. 2021. Thalidomide analo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-18 | MSV000086902 | MassIVE
UnknownAcute lymphoblastic leukemia in patients treated with lenalidomide for multiple myeloma: a safety meta-analysis of randomized controlled trials combined with a retrospective study of the WHO's pharmacovigilance database.
Not available
S-EPMC11473840 | biostudies-literature
UnknownUnidirectional response to bidirectional selection on body size II. Quantitative genetics.
Not available
S-EPMC7593195 | biostudies-literature
GenomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [ChIP-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. ChIP-seq for 2 histone modifications and total H3 (for quantitative normalization) in biological triplicates of cord blood, adult bone marrow, and UNC0638-treated adult bone marrow.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-69516 | biostudies-arrayexpress
UnknownUnidirectional response to bidirectional selection on body size. I. Phenotypic, life-history, and endocrine responses.
Not available
S-EPMC7548191 | biostudies-literature
TranscriptomicsIGR_Raslova_LMMC
Characterization of genetic alterations in monocoyte lineage (CD14+ cells) of two CMML (Chronicle Myelo-Monocytic Leukemia) patients. Previously we have shown that RUNX1 downregulates MYH10 expression in megacaryocyte lineage leading in MYH10 overexpression in platelets of patients wiht RUNX1 geneti...
ORGANISM(S): Homo sapiens 
2013-01-16 | E-MTAB-1121 | biostudies-arrayexpress
TranscriptomicsIGR_Itzykson_CMML
Genomic studies in chronic myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS) and MPN/MDS, have identified common mutations in genes encoding signaling, epigenetic, transcription and splicing factors. Analysis of 18 of these genes in a cohort of 224 c...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-MTAB-1044 | biostudies-arrayexpress
UnknownClinical relevance of IDH1/2 mutant allele burden during follow-up in acute myeloid leukemia. A study by the French ALFA group.
Not available
S-EPMC5927984 | biostudies-literature
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