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TranscriptomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [RNA-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. RNA-Seq in primary adult human erythroid cells treated with UNC0638 or the vehicle control (DMSO) in biological triplicates.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71421 | biostudies-arrayexpress
GenomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [ChIP-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. ChIP-seq for 2 histone modifications and total H3 (for quantitative normalization) in biological triplicates of cord blood, adult bone marrow, and UNC0638-treated adult bone marrow.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-69516 | biostudies-arrayexpress
TranscriptomicsIGR_Itzykson_CMML
Genomic studies in chronic myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS) and MPN/MDS, have identified common mutations in genes encoding signaling, epigenetic, transcription and splicing factors. Analysis of 18 of these genes in a cohort of 224 c...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-MTAB-1044 | biostudies-arrayexpress
TranscriptomicsGenotyping by array of human primary acute myeloid leukemia cells on the Affymetrix 6.0 SNP array to evaluate prognostic relevance
DNA copy number, and LOH using a large set of paired samples (n=108+11), i.e. AML cells at diagnosis and normal leukocytes at remission. Affymetrix 6.0 SNP array were used.
ORGANISM(S): Homo sapiens 
2016-11-02 | E-MTAB-1586 | biostudies-arrayexpress
TranscriptomicsGenotyping of human primary acute myeloid leukemia cells on the Affymetrix 6.0 SNP array to validate direct sequecing of the TET2 locus in genomic DNA
The TET2 locus was analyzed for DNA copy number, and LOH using a large set of paired samples (n=106), i.e. AML cells at diagnosis and normal peripheral blood mononuclear cells at remission; and AML at diagnosis (n=6). Affymetrix 6.0 SNP array were used.
ORGANISM(S): Homo sapiens 
2010-06-01 | E-MTAB-278 | biostudies-arrayexpress
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