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ProteomicsTHEM6-mediated lipid remodelling sustains stress resistance in cancer (Part1 : AP-MS)
Despite the clinical benefit of androgen-deprivation therapy (ADT), the majority of patients with advanced prostate cancer (PCa) ultimately develop lethal castration-resistant prostate cancer (CRPC). In this study, we identified thioesterase superfamily member 6 (THEM6) as a marker of ADT resistance...
ORGANISM(S): Homo sapiens (Human) 
2021-12-11 | PXD024407 | Pride
Castration-resistant prostate cancer Cancer metabolism Endoplasmic reticulum Cancer proteomics 
ProteomicsTHEM6-mediated lipid remodelling sustains stress resistance in cancer (Part2 : THEM6 KO in 22rv1)
Despite the clinical benefit of androgen-deprivation therapy (ADT), the majority of patients with advanced prostate cancer (PCa) ultimately develop lethal castration-resistant prostate cancer (CRPC). In this study, we identified thioesterase superfamily member 6 (THEM6) as a marker of ADT resistance...
ORGANISM(S): Homo sapiens (Human) 
2021-12-11 | PXD024456 | Pride
Castration-resistant prostate cancer Cancer metabolism Endoplasmic reticulum Cancer proteomics 
ProteomicsTHEM6-mediated lipid remodelling sustains stress resistance in cancer (Part3 : THEM6 KO in LNCaP AI)
Despite the clinical benefit of androgen-deprivation therapy (ADT), the majority of patients with advanced prostate cancer (PCa) ultimately develop lethal castration-resistant prostate cancer (CRPC). In this study, we identified thioesterase superfamily member 6 (THEM6) as a marker of ADT resistance...
ORGANISM(S): Homo sapiens (Human) 
2021-12-11 | PXD024433 | Pride
Castration-resistant prostate cancer Cancer metabolism Endoplasmic reticulum Cancer proteomics 
UnknownTHEM6-mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer.
Not available
S-EPMC8899912 | biostudies-literature
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