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Fibroblasts can be directly reprogrammed to induced renal tubular epithelial cells (iRECs) using four transcription factors. These engineered cells may be used for disease modeling, cell replacement therapy or drug and toxicity testing. Direct reprogramming induces drastic changes in the transcripti...
2021-08-20 | MTBLS608 | MetaboLights
Discovery of therapies that are able to correct defective CFTR requires patient derived in vitro pre-clinical cell models to be developed. Two main approaches exist to expand bronchial and nasal cultures, such as conditionally reprogrammed cells (CRC) and feeder free dual SMAD inhibition (SMADi) to ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-05 | PXD018386 | Pride
Epigenetic profiling of hepatocyte, reprogrammed hepatocyte, and biliary cells
Non-alcoholic fatty liver disease is now considered the most common form of chronic liver disease. It is a complex metabolic disease that silently progresses into non-alcoholic steatohepatitis (NASH). In fact, NASH is the tipping point for pericellular fibrosis, cirrhosis and hepatocellular carcinom...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-19 | MSV000088003 | MassIVE
Global RNA expression of fibromodulin reprogrammed human BJ fibroblasts
RNA Sequencing for reprogrammed beta cells
DNA methylation is an important epigenetic mechanism, affecting normal development and playing a key role in reprogramming epigenomes during stem cell derivation. Here we report on DNA methylation patterns in native monkey embryonic stem (ES) cells, fibroblasts and ES cells generated through somatic...
ORGANISM(S): Macaca mulatta 
Transcriptional profiling of hepatocyte, reprogrammed hepatocyte, and biliary cells [human]
RNA-seq of human dermal fibroblasts reprogrammed into cardiomyocytes
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