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GenomicsGenome wide localization of Activation induced cytidine deaminase (AID), Spt5, and RNA Polymerase II (PolII) in mouse
Activation induced cytidine deaminase (AID) initiates antibody gene diversification by creating U:G mismatches. However, AID is not specific for antibody genes. Off-target lesions can activate oncogenes or cause chromosome translocations. Despite its importance in these key transactions little is kn...
ORGANISM(S): Mus musculus 
2010-10-05 | E-GEOD-24178 | biostudies-arrayexpress
ProteomicsSmooth muscle cell spheroids as 3D model of phenotypic plasticity and matrix deposition revealed by 2D-3D proteomics
Our study aims to compare 2D adherent and 3D floating (spheroid) cell cultures of in the context of cellular physiology and in atherosclerosis modelling. Here, we utilize vascular smooth muscle cells from rat aorta to profile 2D and 3D proteomes.
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-07 | PXD069144 | Pride
Smoot muscle cell  spheroids  3d cell culture  lc-ms/ms 
ProteomicsAntidiabetic PPARγ Antidiabetic PPARγ agonist Pioglitazone inhibits cell proliferation and induces metabolic reprogramming in prostate cancer cellsonist Pioglitazone inhibits cell proliferation and induces metabolic reprogramming in prostate cancer cells
Background: Prostate cancer (PCa) and Type 2 diabetes (T2D) are two major health risks that often occur concurrently in men. Studies predict that diabetic PCa patients have a reduced risk of PCa progression, while other studies show contradicting data. This impedes unraveling the connection between ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-11 | PXD060526 | Pride
Prostate cancer cells  ppar agonists  proteome and metabolic reprogramming 
ProteomicsSILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy
Post-hepatectomy liver failure (PHLF) remains a significant risk for patients undergoing partial hepatectomy (PHx). Reliable prognostic markers and treatments to enhance liver regeneration are lacking. Plasma nanoparticles, including lipoproteins, exosomes, and extracellular vesicles (EVs), can refl...
ORGANISM(S): Homo sapiens (Human) 
2025-08-11 | PXD059885 | Pride
Plasma extracellular vesicles Post-hepatectomy liver failure Proteomics 
UnknownSeven-year outcomes following intensive anti-vascular endothelial growth factor therapy in patients with exudative age-related macular degeneration.
Not available
S-EPMC10022151 | biostudies-literature
TranscriptomicsB cell super-enhancers and regulatory clusters recruit AID tumorigenic activity
The antibody gene mutator AID promiscuously damages oncogenes and B cell identity genes leading to chromosomal translocations and tumorigenesis. Why non-immunoglobulin loci are susceptible to AID activity is unknown. Here we study AID-mediated lesions in the context of nuclear architecture and the B...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-62063 | biostudies-arrayexpress
UnknownExpanding the Toolbox of Simple, Cost-Efficient, and Automatable Methods for Quantifying Surface Functional Groups on NanoparticlesPotentiometric Titration.
Not available
S-EPMC12532055 | biostudies-literature
UnknownSequence-Based In-silico Discovery, Characterisation, and Biocatalytic Application of a Set of Imine Reductases.
Not available
S-EPMC6120462 | biostudies-literature
UnknownSynthesis of Estrone Heterodimers and Evaluation of Their In Vitro Antiproliferative Activity.
Not available
S-EPMC11050183 | biostudies-literature
UnknownDuplex formation between the sRNA DsrA and rpoS mRNA is not sufficient for efficient RpoS synthesis at low temperature.
Not available
S-EPMC3917986 | biostudies-literature
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