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Background: Colorectal cancer is the third most common and the fourth most lethal cancer in the world. In the majority of cases, patients are diagnosed at an advanced stage or even metastatic, thus explaining the high mortality. The standard protocol for treating patients with locally advanced non-m...
ORGANISM(S): Homo sapiens (Human) 
2018-06-25 | PXD008440 | Pride
Standard therapy of rectal cancer comprises a combination of local radio- and systemic chemotherapy prior to surgery. Despite comparable tumor morphology and stage the outcome of such neoadjuvant therapy is heterogeneous and the underlying factors that define therapy response are unknown. Here we de...
ORGANISM(S): Homo sapiens 
2023-08-12 | GSE156281 | GEO
Therapy-induced senescence of cancer-associated fibroblasts determines survival in rectal cancer
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