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ProteomicsA system-wide approach to monitor responses to synergistic BRAF and EGFR inhibition in colorectal cancer cells
Molecular heterogeneity of tumors, epigenetic changes and a diverse range of molecular mechanisms are main contributors to drug resistance, which represents one of the great challenges in cancer treatment. A deeper understanding of the molecular biology of cancer has resulted in better targeted ther...
ORGANISM(S): Homo sapiens (Human) 
2018-07-16 | PXD007740 | Pride
Ptpn11 Proteomics Colorectal cancer Multi-omics Drug resistance Braf(v600e) Phosphoproteomics Transcriptomics Egfr 
ProteomicsTUMOUR KINOME RE-WIRING GOVERNS RESISTANCE TO PALBOCICLIB IN OESTROGEN RECEPTOR POSITIVE BREAST CANCERS, HIGHLIGHTING NEW THERAPEUTIC MODALITIES
Estrogen receptor positive (ER+) breast cancers are the most common type of breast cancer. Despite the great efficacy of endocrine therapies, resistance remains a problem. Therefore, there is an immediate need for new, effective therapies in ER+ BC. In this study, we have explored the role of a pote...
ORGANISM(S): Homo sapiens (Human) 
2020-04-29 | PXD005514 | Pride
Breast cancer Resistance Palbociclib Phosphoproteomics 
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