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MetabolomicsNuclear Magnetic Resonance-Based Blood Metabolic Profiles of Rats Exposed to Short-Term Caloric Restriction
Caloric restriction increases life-span of a number of organisms. The relationship between the increase in life-span and the extent of caloric restriction, however, varies among species. The underlying mechanisms are yet unknown, but appear to be related to changes in metabolism. In order to investi...
2014-09-05 | MTBLS114 | MetaboLights
MetabolomicsSexual dimorphism in the fetal cardiac response to maternal nutrient restriction
Poor maternal nutrition causes intrauterine growth restriction (IUGR); however, its effects on fetal cardiac development are unclear. We have developed a baboon model of moderate maternal undernutrition, leading to IUGR. We hypothesized that the IUGR affects fetal cardiac structure and metabolism. S...
2018-04-30 | MTBLS426 | MetaboLights
MetabolomicsDietary leucine restriction remodels the gut microbiota and serum glycerophospholipids to combat obesity

Abstract

Background The gut microbiota mediates dietary impacts on host metabolism, but the roles of specific amino acids remain elusive. We investigated the mechanism by which dietary leucine restriction combats obesity.

Methods Combining Mendelian randomization in humans with interv...

2025-11-07 | MTBLS13281 | MetaboLights
MetabolomicsNon-canonical Metabolic and Molecular Effects of Calorie Restriction Are Revealed by Varying Temporal Conditions

Calorie restriction (CR) extends lifespan and healthspan in diverse species. However, comparing ad libitum (AL) and CR-fed mice is challenging due to their significantly different feeding patterns. CR-fed mice consume their daily meal in approximately 2 hours, subjecting themselves to a prol...

2025-07-07 | MTBLS10795 | MetaboLights
MetabolomicsDietary restriction of lysine reduces pediatric obesity through enhancing Parabacteroides goldsteinii-produced 1,4-Methylimidazoleacetic acid

The influence of amino acid restriction on obesity may be related to the gut microbiome, but the role and mechanism of lysine restriction (LR) on pediatric obesity is largely undefined. Here, we found plasma lysine levels were significantly higher in obese patients than healthy controls of childr...

2025-09-18 | MTBLS13011 | MetaboLights
MetabolomicsA high-fiber diet mimics aging-related signatures of caloric restriction in mammals

Caloric restriction (CR) delays aging-related hallmarks in various organisms by slowing growth and development while enhancing metabolic homeostasis. However, desirable diets that harness the metabolic benefits of CR without imposing food intake restrictions remain elusive. Here we evaluated the ...

2025-06-13 | MTBLS12479 | MetaboLights
MetabolomicsSingle-cell RNA sequencing decipher hepatic injury and APOA4 as a biomarker in males with intrauterine growth restriction

Intrauterine growth restriction (IUGR) is associated with increased relative liver weight at birth, hepatic function decline and a higher risk for chronic liver and cardiovascular diseases in adults. Precise mechanisms of early developmental plasticity to intervene in poor fetal programming and a...

2023-09-25 | MTBLS6881 | MetaboLights
MetabolomicsCaloric Restriction vs drugs
Not available
ORGANISM(S): Mus musculus 
ST000090 | MetabolomicsWorkbench
MetabolomicsProlonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice
Emerging new evidence highlights the importance of prolonged daily fasting periods for the health and survival benefits of calorie restriction (CR) and time-restricted feeding (TRF) in male mice; however, little is known about the impact of these feeding regimens in females. We placed 14-month-old f...
2024-05-14 | MTBLS790 | MetaboLights
MetabolomicsA data integration multi-omics approach to study calorie restriction-induced changes in insulin sensitivity
The mechanisms responsible for weight loss-induced improvement in insulin sensitivity are partially understood. Greater insight can now be achieved through deep phenotyping and data integration. Here, we used an integrative approach to investigate associations between changes in insulin sensitivity ...
2021-02-11 | MTBLS653 | MetaboLights
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