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TranscriptomicsTranscription profiling of mouse single retinal cells reveals individual retinal progenitor cells display extensive heterogeneity of gene expression
The development of complex tissues requires that mitotic progenitor cells integrate information from the environment. The highly varied outcomes of such integration processes undoubtedly depend at least in part upon variations among the gene expression programs of individual progenitor cells. To dat...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9811 | biostudies-arrayexpress
ProteomicsTracing retinal progenitors cells and photoreceptors from mouse retinal organoids
Retinal organoids have become valuable 3D model for translational and developmental research. The knowledge of the limitations of the system ensures its sensible use. All retinal cell types originate from the differentiation of retinal progenitor cells. The properties of retinal progenitors in 3D cu...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-14 | PXD039309 | Pride
Retinal organoid Mouse embryonic stem cells Retinal progenitor cells 
ProteomicsCasz1 interactome via BioID on primary mouse retinal cells
Control versus Casz1 BioID on mouse primary retinal cells. BioID constructs were introduced via nucleofection. Cultured cells were harvested, nuclei extracted, and BioID was performed as per standard procedures.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-06-17 | MSV000085598 | MassIVE
TranscriptomicsUnderstanding adult human progenitor cells
Overarching aim is to achieve a greater understanding of the control of progenitor cells within the adult human retina within the normal and diseased retinal microenvironment. Specifically we will assess via our experimental designs: (i) the control of CD133+ retinal cell populations that display mi...
ORGANISM(S): Homo sapiens 
2009-02-06 | E-GEOD-14733 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse developing retinal ganglion and amacrine cells reveals molecular heterogeneity of
During development of the central nervous system (CNS), cycling uncommitted progenitor cells give rise to a variety of distinct neuronal and glial cell types. As these different cell types are born, they progress from newly specified cells to fully differentiated neurons and glia. In order to defi...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9812 | biostudies-arrayexpress
ProteomicsRetinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina
Age-related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the loss of the retinal pigment epithelium (RPE) and photoreceptors and/or retinal and choroidal angiogenesis. Here we use AMD patient specific RPE cells with the Y402H high-risk polymorphism in the comp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-01-21 | MSV000088713 | MassIVE
GenomicsTranscriptomic analysis of progenitor marker expression in retinal cells
Transcriptomic analysis of progenitor marker expression in retinal cells
PRJNA480689 | ENA
ProteomicsIn vitro and in vivo proteomic comparison of human neural progenitor cell-induced photoreceptor survival
Retinal degenerative diseases are some of the leading causes of blindness with few treatments. Various cell-based therapies have aimed to slow the progression of vision loss by preserving light-sensing photoreceptor cells. A subretinal injection of human neural progenitor cells (hNPCs) into the Roya...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2018-12-17 | PXD011491 | Pride
Retinal degeneration Cell therapy Stem cells Neural progenitors Retina 
GenomicsFate-restricted retinal progenitor cells adopt a molecular profile and spatial position distinct from multipotent progenitor cells
Fate-restricted retinal progenitor cells adopt a molecular profile and spatial position distinct from multipotent progenitor cells
PRJNA420373 | ENA
GenomicsTranscriptomic analysis of normal mouse retinal and conditional medium cultured retinal progenitor cells
Transcriptomic analysis of normal mouse retinal and conditional medium cultured retinal progenitor cells
PRJNA480385 | ENA
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