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Wnt Regulates Cellular Differentiation and Retinoid Metabolism Genes in the Mouse Stomach
Single cell transcriptomics of lung retinoid-containing cells
The liver X receptors (LXRs) are nuclear receptors that form permissive heterodimers with retinoid X receptor (RXR) and are important regulators of lipid metabolism in the liver. We have recently shown that RXR agonist-induced hypertriglyceridemia and hepatic steatosis in mice is dependent on LXR an...
ORGANISM(S): Mus musculus 
The main active metabolite of Vitamin A, all-trans retinoic acid (RA), is responsible for proper cellular function and tissue organization. The role of RA has been extensively studied in development, but there is limited research on its role in the adult heart. Cellular retinol-binding protein, type...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD029349 | Pride
Retinoid-related orphan receptors RORalpha and RORgamma are both expressed in liver; however, their physiological functions have not yet been clearly defined. RORalpha1 and RORgamma1, but not RORalpha4, show an oscillatory pattern of expression during circadian rhythm. To obtain insight into the phy...
ORGANISM(S): Mus musculus 
In vivo pathways of natural retinoid metabolism and elimination have not been well characterized in primary myeloid cells, even though retinoids and retinoid receptors have been strongly implicated in regulating myeloid maturation. Using a UAS-GFP reporter transgene, and retrovirally expressed Gal4-...
ORGANISM(S): Mus musculus 
Background & Aims: While recognized as a key regulator of gastrointestinal tissues, Wnt function in the stomach is poorly understood. This study aimed to define Wnt functions and identify Wnt-regulated genes in the stomach. Methods: Wnt signaling was localized using reporter mice. Proliferation was ...
ORGANISM(S): Mus musculus 
2025-12-29 | GSE314919 | GEO
The gut microbiota has been implicated in obesity and cardiometabolic diseases, although evidence in humans is scarce. We investigated how gut microbiota manipulation by antibiotics (7-day administration of amoxicillin, vancomycin, or placebo) affects host metabolism in 57 obese, prediabetic men. Va...
ORGANISM(S): Homo sapiens 
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