Sort   by:  
 Page size 
ProteomicsAn impaired respiratory electron chain triggers down-regulation of the energy metabolism and de-ubiquitination of solute carrier amino acid transporters
We integrated metabolome and proteome profiles of the parental cell line 143B.TK- versus ?0, including PTM analyses such as phosphorylation and ubiquitination to characterize the impact of the absence of mtDNA for the entire cell. For quantitative proteome profiling, we used a shotgun LC-MS/MS appro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080873 | MassIVE
Proteomicslincomycin treatment wild type and gun1-101
Retrograde signals emanate from the DNA-containing cell organelles (plastids and mitochondria) and control the expression of a large number of nuclear genes in response to environmental and developmental cues. Previous studies on retrograde signaling mainly analyzed the regulation of nuclear gene ex...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-06-05 | PXD011759 | Pride
Arabidopsis Retrograde signaling 
GenomicsPeroxisomal retrograde signaling in C. elegans
Peroxisomal retrograde signaling in C. elegans
PRJNA657442 | ENA
ProteomicsProNGF elicits retrograde axonal degeneration of basal forebrain neurons via p75NTR and induction of APP
Basal forebrain cholinergic neurons (BFCNs) extend long projections to multiple targets in the brain to regulate cognitive functions, and are compromised in numerous neurodegenerative disorders. Our previous study showed that injury to the target region of these neurons affects their viability in vi...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-06 | PXD043846 | Pride
Key words: proneurotrophin Axon degeneration P75ntr Axonal protein synthesis 
TranscriptomicsExpression data from Arabidopsis thaliana seedlings with altered enzymes activity of the tetrapyrrole biosynthesis pathway
The CHLD and CHLM genes encode proteins involved in tetrapyrrole biosynthesis pathway. It was proposed that intermediates like magnesium protoporphyrin might play a role in retrograde plastid-to-nucleus signaling. In the present work we provide evidence that altered enzymes activity of the tetrapyrr...
ORGANISM(S): Arabidopsis thaliana 
2013-04-01 | E-GEOD-41884 | biostudies-arrayexpress
TranscriptomicsArabidopsis transcription factor ANAC017 is a necessary and central control point for normal transcriptome changes in response to reactive oxygen signals, such as H2O2, and specific mitochondrial retrograde stress signals
Stresses that target mitochondrial function lead to altered transcriptional responses for 100-1000s of genes genome wide, and are signalled via retrograde communication pathways within the cell. rao2 mutants contain a mutation in the NAC family transcription factor ANAC017 and cannot induce stress r...
ORGANISM(S): Arabidopsis thaliana 
2013-01-30 | E-GEOD-41136 | biostudies-arrayexpress
TranscriptomicsPeroxisomal retrograde signaling in C. elegans
Distinct retrograde signaling pathways have been identified for several cellular organelles. These pathways are important to maintain the function of these organelles in response to organelle-specific stress. Using Caenorhabditis elegans, we show for the first time that such a retrograde signaling a...
ORGANISM(S): Caenorhabditis elegans 
2020-12-19 | GSE156318 | GEO
UnknownHomeostatic regulation of STING by retrograde membrane traffic to the ER.
Not available
S-EPMC7782846 | biostudies-literature
UnknownRegulation of alternative splicing by retrograde and light signals converges to control chloroplast proteins.
Not available
S-EPMC9950775 | biostudies-literature
ProteomicsAn impaired respiratory electron chain triggers retrograde response and de-ubiquitination of solute carrier amino acid transporters
Hundreds of genes have been associated with respiratory chain disease so far. Elimination of the respiratory electron chain by depleting the entire mitochondrial DNA (mtDNA, ��0 cells) has therefore one of the most severe impacts on the energy metabolism in eukaryotic cells. Here, we integrated prot...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD002270 | Pride
Proteome profiling Ρ0 cells Metabolome profiling Mass spectrometry Ubiquitination Retrograde response Oxphos deficiency 
Sort   by:  
 Page size