Retrograde trafficking

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Functional Dissection of the Retrograde Shiga Toxin Trafficking Inhibitor Retro-2

The retrograde transport inhibitor Retro-2 has a protective effect on cells and in mice against Shiga-like toxins and ricin. Retro-2 causes toxin accumulation in early endosomes, and the relocalization of the Golgi SNARE protein syntaxin-5 to the endoplasmic reticulum. The molecular mechanisms by wh...

ORGANISM(S): Homo sapiens (Human)

2020-02-24 | PXD015642 | Pride

Host-derived Extracellular Trypsin Primes Shiga toxin 2a for Enhanced Intoxication with Reduced Dependence on Retrograde Trafficking

PRJNA1471920 | ENA

Functional dissection of the retrograde Shiga toxin trafficking inhibitor Retro-2.

Not available

S-EPMC7039708 | biostudies-literature

Host-derived Extracellular Trypsin Primes Shiga toxin 2a for Enhanced Intoxication with Reduced Dependence on Retrograde Trafficking

Hemolytic uremic syndrome is a complication of STEC infections. Although canonical Stx intoxication was known to depend upon retrograde trafficking to the Golgi apparatus and endoplasmic reticulum, the impact of extracellular proteolytic priming on the retrograde pathway remained poorly defined. In ...

ORGANISM(S): Mus musculus

2026-05-28 | GSE333658 | GEO

ARF4-mediated retrograde trafficking as a driver of chemoresistance in glioblastoma.

Not available

S-EPMC11300013 | biostudies-literature

β-Amyloid impairs axonal BDNF retrograde trafficking.

Not available

S-EPMC3038182 | biostudies-literature

Retrograde trafficking of AB₅ toxins: mechanisms to therapeutics.

Not available

S-EPMC3773303 | biostudies-literature

Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b.