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TranscriptomicsELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal Via the PI3K/AKT Pathway
ELABELA (ELA) is a peptide hormone required for heart development that signals via the Apelin Receptor (APLNR, APJ). ELA is also abundantly secreted by human embryonic stem cells (hESCs), which do not express APLNR. Here we show that ELA signals in a paracrine fashion in hESCs to maintain self-rene...
ORGANISM(S): Homo sapiens 
2015-09-20 | E-GEOD-71949 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in normal and Otx2-/- early gastrulating mouse embryos
We compared gene expression profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in t...
ORGANISM(S): Mus musculus 
2003-09-25 | E-GEOD-683 | biostudies-arrayexpress
UnknownHOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring.
Not available
S-EPMC9226161 | biostudies-literature
UnknownLoss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects.
Not available
S-EPMC4424953 | biostudies-literature
UnknownStructural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
Not available
S-EPMC7794362 | biostudies-literature
UnknownHuman DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding.
Not available
S-EPMC6295727 | biostudies-literature
UnknownMultiple self-healing palmoplantar carcinoma: a familial predisposition to skin cancer with primary palmoplantar and conjunctival lesions.
Not available
S-EPMC4269804 | biostudies-literature
UnknownHomozygous Null TBX4 Mutations Lead to Posterior Amelia with Pelvic and Pulmonary Hypoplasia.
Not available
S-EPMC6904794 | biostudies-literature
UnknownDiscriminative Features in Three Autosomal Recessive Cutis Laxa Syndromes: Cutis Laxa IIA, Cutis Laxa IIB, and Geroderma Osteoplastica.
Not available
S-EPMC5372648 | biostudies-literature
TranscriptomicsscRNA-seq of human fetal lung explants with R-SPONDIN Inhibition and human fetal lung primary tissue
Here, we used single cell RNA-sequencing (scRNA-seq) to profile 13-week post-conception distal human fetal lung explants cultured in an air liquid interface system and treated with an LGR5 ectodomain adenovirus that inhibits R-Spondin function or control adenovirus. A third, non-infected, condition ...
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-10662 | biostudies-arrayexpress
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