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TranscriptomicsSRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
Increased expression of SIRT1 extends the lifespan of lower organisms and delays the onset of age-related diseases in mammals. Here, we show that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet. This is accompanied by improve...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-49000 | biostudies-arrayexpress
MetabolomicsObesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer (Murine serum assays)

Cancer cells exhibit metabolic plasticity to meet oncogene-driven dependencies while coping with nutrient availability. A better understanding of how systemic metabolism impacts the accumulation of metabolites that reprogram the tumor microenvironment and drive cancer could facilitate development...

2024-04-10 | MTBLS3316 | MetaboLights
MetabolomicsObesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer (Murine prostate assays)

Cancer cells exhibit metabolic plasticity to meet oncogene-driven dependencies while coping with nutrient availability. A better understanding of how systemic metabolism impacts the accumulation of metabolites that reprogram the tumor microenvironment and drive cancer could facilitate development...

2024-04-10 | MTBLS3317 | MetaboLights
ProteomicsPhosphoproteomic profiling of WNTinib
Phosphoproteome profiling small molecule on sensitive and insensitive murineHCC tumour organoids
ORGANISM(S): Mus Musculus (mouse) 
2023-03-16 | PXD024958 | JPOST Repository
TranscriptomicsEffects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Calorie restriction (CR) is the most robust non-genetic intervention to universally delay the onset of age-related diseases and extend mean and maximum lifespan. However, species, strain, sex, diet, age of onset, and level of CR are emerging as important variables to consider for a successful CR res...
ORGANISM(S): Mus musculus 
2016-06-27 | E-GEOD-81959 | biostudies-arrayexpress
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
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