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TranscriptomicsTranscription profiling of human monocyte derived dendritic cells treated with DC-SIGN initiates an immature dendritic cell phenotype triggering Rho activation that is utilised by HIV-1
DC-SIGN is a C-type lectin expressed by dendritic cells (DCs) that binds HIV-1, sequestering it within multivesicular bodies to facilitate transmission to CD4+ T cells. Here we characterize the molecular basis of signalling through DC-SIGN by large-scale gene expression profiling and phosphoproteome...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6090 | biostudies-arrayexpress
TranscriptomicsIL-8 Confers Acquired Resistance to EGFR Inhibitors through Regulating Stem Cell-like Properties in Lung Cancer
Previous study has demonstrated that PC9/gef cells are resistant to gefitinib-induced aspoptosis. To investigate the regulators contributed to gefitinib resistance in lung cancer, we analyzed the gene expression profiles between PC9 and PC9/gef cells. Our results showed that IL-8 contributes to gefi...
ORGANISM(S): Homo sapiens 
2015-08-12 | E-GEOD-60189 | biostudies-arrayexpress
UnknownFgd5 is a Rac1-specific Rho GEF that is selectively inhibited by aurintricarboxylic acid.
Not available
S-EPMC7849785 | biostudies-literature
UnknownMolecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells.
Not available
S-EPMC6548299 | biostudies-literature
UnknownThe Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcription.
Not available
S-EPMC2738780 | biostudies-literature
UnknownThe ubiquitin-like protein LC3 regulates the Rho-GEF activity of AKAP-Lbc.
Not available
S-EPMC2788875 | biostudies-literature
UnknownRegulation of Rho-GEF Rgf3 by the arrestin Art1 in fission yeast cytokinesis.
Not available
S-EPMC4310737 | biostudies-literature
UnknownTEM4 is a junctional Rho GEF required for cell-cell adhesion, monolayer integrity and barrier function.
Not available
S-EPMC3730241 | biostudies-literature
TranscriptomicsmiRNA array analysis following gefinitib/luteolin administration to PC-3 cells
To determine if any altered miRNA expression is actually involved in the growth inhibition and/or cell death induction by luteolin and/or gefitinib, we performed miR-array analysis using RNA from PC-3 cells after 24h of treatment with 60μM luteolin and/or 60μM gefitinib. PC-3 cells were treated fo...
ORGANISM(S): Homo sapiens 
2014-06-29 | E-GEOD-53178 | biostudies-arrayexpress
UnknownThe Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.
Not available
S-EPMC4294672 | biostudies-literature
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