Rhoa/rock - OmicsDI

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UNIPROT ID/AC

P52565 (1)
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Q15052 (1)
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O15530 (1)
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Q8WYR1 (1)
Q16828 (1)
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CHEBI ID

CHEBI:16618 (1)
CHEBI:16152 (1)
CHEBI:15996 (1)
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CHEBI:189785 (1)
CHEBI:165214 (1)
CHEBI:93694 (1)
CHEBI:189897 (1)
CHEBI:1989 (1)
CHEBI:174952 (1)
CHEBI:175811 (1)
CHEBI:169854 (1)
CHEBI:192061 (1)
CHEBI:49101 (1)
CHEBI:189986 (1)
CHEBI:4222 (1)
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CHEBI:186847 (1)
CHEBI:192123 (1)
CHEBI:143854 (1)
CHEBI:169806 (1)
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CHEBI:88429 (1)
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CHEBI:191735 (1)
CHEBI:77512 (1)
CHEBI:521021 (1)
CHEBI:156193 (1)
CHEBI:193728 (1)

Metabolite Name

L-(-)-Cystine (1)
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5-Methyl-THF (1)
3-(2H-1,3-benzodioxol-5-yl)-3-oxopropanoic acid (1)
(+/-)18-HETE (1)
2-[(2-amino-3-methylpentanoyl)amino]-3-methylpentanoic acid (1)
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione (1)
3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyloxy)benzoic acid (1)
(S)-Glutamic acid (1)
(R)-Serine (1)
5'-Cytidylic acid (1)
Beta-Nicotinamide Mononucleotide (1)
2-Acetyl-3,5,5,6,8,8-hexamethyl-5,6,7,8-tetrahydronaphthalene (1)
PC(18:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))[U] (1)
Alpha-Terpineol formate (1)
P-Butylaminobenzoic acid (1)
N-(2-Phenylethyl)-acetamide (1)
6-Chloroapigenin (1)
[2-hydroxy-1-(1-oxo-1H-isochromen-3-yl)butoxy]sulfonic acid (1)
N,N'-bis(3-aminopropyl)butane-1,4-diamine (1)
5-(hydroxymethyl)-2-Furancarboxylic acid (1)
Alpha-D-Galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosamine (1)
L(-)-Pipecolinic acid (1)
3-methyl-2-[(5-oxopyrrolidine-2-carbonyl)amino]pentanoic acid (1)
N-Desmethyl-o-O-sulfate rosiglitazone (1)
DIHYDRO-beta-TUBAIC ACID (1)
Gamma-Glutamylaspartic acid (1)
2-amino-4-({1-[(carboxymethyl)-C-hydroxycarbonimidoyl]-2-[(3-oxo-1-phenylpropyl)sulfanyl]ethyl}-C-hydroxycarbonimidoyl)butanoic acid (1)
N-(3,4-Dichlorophenyl)-malonamate (1)

IsPrivate

False (1)

First Public Date

2024 (6)
2022 (6)
2026 (5)
2025 (5)
2020 (3)
2023 (2)
2014 (2)
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Modelling Approach

Ordinary differential equation model (1)

Study type

Transcription profiling by array (20)
RNA-seq of coding RNA (8)
RNA-seq of coding RNA from single cells (4)
ChIP-seq (3)
High-throughput sequencing (1)
Genotyping by array (1)
Comparative genomic hybridization by array (1)
ScATAC-seq (1)
Methylation profiling by array (1)

Release Date

2022 (48)
2023 (47)
2016 (44)
2025 (40)
2020 (40)
2021 (40)
2019 (38)
2024 (38)
2017 (37)
2015 (37)
2018 (36)
2013 (28)
2012 (25)
2014 (23)
2009 (18)
2010 (17)
2008 (15)
2011 (12)
2026 (9)
2007 (5)
2006 (4)
2005 (2)
2004 (2)
2001 (1)

Lab affiliation

Center for Integrative Genomics, CIG, UNIL Sorge, CH1015 Lausanne, Switzerland (1)
Department of Surgery Cedars-Sinai Medical Center (1)
Division of Cancer Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, The United Kingdom. (1)
Univ. Bordeaux, INSERM, BRIC, U1312, Bordeaux, France (1)

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Xiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via TGR5-FAK-RhoA/Rock signaling revealed by integrated metabolomics and proteomics

Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate diarrhea, but its mechanisms remain unclear. This study aimed to explore the underlying regulatory mechani...

2025-09-03 | MTBLS12931 | MetaboLights

Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis.

We have discovered a previously uncharacterized tumor suppressor function of Numb in the homeostasis of the normal bladder mucosa. Targeted ablation of Numb in the basal layer of the urothelium drives spontaneous bladder tumorigenesis, driving progression from preneoplastic to preinvasive and overtl...

ORGANISM(S): Homo sapiens Mus musculus

2024-10-11 | GSE256272 | GEO

RhoA/ROCK Regulates Prion Pathogenesis by Controlling Connexin 43 Activity.

Not available

S-EPMC7072953 | biostudies-literature

Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis.

PRJNA1078848 | ENA

RhoA controls retinoid signaling by ROCK dependent regulation of retinol metabolism.

Not available

S-EPMC5997168 | biostudies-literature

Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles.

Not available

S-EPMC10589999 | biostudies-literature

Localized Rho GTPase Activation Regulates RNA Dynamics and Compartmentalization in Tumor Cell Protrusions

mRNA trafficking and local protein translation are associated with protrusive cellular domains, such as neuronal growth cones, and deregulated control of protein translation is associated with tumor malignancy. We show here that activated RhoA, but not Rac1, is enriched in pseudopodia of MSV-MDCK-IN...

ORGANISM(S): Canis lupus familiaris

2010-05-18 | E-GEOD-13253 | biostudies-arrayexpress

RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes.

Not available

S-EPMC6361616 | biostudies-literature

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.

Not available

S-EPMC4394241 | biostudies-literature

RhoA-ROCK Inhibition Reverses Synaptic Remodeling and Motor and Cognitive Deficits Caused by Traumatic Brain Injury.

Not available

S-EPMC5587534 | biostudies-literature