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GenomicsA SNF2 protein targets variable copy number repeats and thereby influences allele-specific expression
ATRX is an X-linked gene of the SWI/SNF family whose role in vivo is currently unknown. Mutations in ATRX cause syndromal mental retardation. ATRX binds to tandem repeat (TR) sequences both in heterochromatin (e.g. telomeres) and euchromatin. Genes associated with these TRs can be dysregulated when ...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-22162 | biostudies-arrayexpress
TranscriptomicsHuman thyroid adenomas, carcinomas, and normals
Human samples of various thyroid carcinomas, adenomas, and normals, each from a different patient, had mRNA assays performed using Affymetrix HG_U133A arrays, with 22283 probe-sets. The 99 samples consisted of 4 normals, 10 follicular adenomas, 13 follicular carcinomas, 7 oncocytic adenomas, 8 onco...
ORGANISM(S): Homo sapiens 
2011-02-09 | E-GEOD-27155 | biostudies-arrayexpress
TranscriptomicsArabidopsis defense against Botrytis cinerea: chronology and regulation deciphered by high-resolution temporal transcriptomic analysis (tga3-2 knockout data)
Transcriptional reprogramming forms a major part of a plant's response to pathogen infection. Many individual components and pathways operating during plant defense have been identified but our knowledge of how these different components interact is still rudimentary. We have generated a high-resolu...
ORGANISM(S): Arabidopsis thaliana 
2012-10-03 | E-GEOD-39597 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type, dcgrA knock out and reconstituted wild type Aspergillus fumigatus to determine the contribution of CgrA to ribosome biogenesis
Study to determine the contribution of CgrA to ribosome biogenesis in Aspergillus fumigatus.
ORGANISM(S): Aspergillus fumigatus 
2008-01-03 | E-MEXP-1324 | biostudies-arrayexpress
TranscriptomicsArabidopsis defense against Botrytis cinerea: chronology and regulation deciphered by high-resolution temporal transcriptomic analysis (time series)
A novel experimental design strategy (A Mead et al, in preparation), based on the principle of the M-bM-^@M-^\loop designM-bM-^@M-^], was developed to enable efficient extraction of information about key sample comparisons using a two-colour hybridisation experimental system. With 192 distinct sampl...
ORGANISM(S): Arabidopsis thaliana 
2012-10-02 | E-GEOD-29642 | biostudies-arrayexpress
Unknown80 questions for UK biological security.
Not available
S-EPMC7787535 | biostudies-literature
GenomicsEGAD00000000054
NCI-H209 is an immortal cell line derived from a bone marrow metastasis of a patient with small cell lung cancer, taken before chemotherapy. The specimen showed histologically typical small cells with classic neuroendocrine features. NCI-BL209 is an EBV-transformed B-cell line derived from the same ...
EGAD00000000054 | EGA
GenomicsA small cell lung cancer genome reports complex tobacco exposure signatures
Cancer is driven by mutation. Worldwide, tobacco smoking is the major lifestyle exposure that causes cancer, exerting carcinogenicity through 60 chemicals that bind and mutate DNA. Using massively parallel sequencing technology, we sequenced a small cell lung cancer cell line, NCI-H209, to explore t...
EGAS00000000051 | EGA
UnknownPredictive biomarkers for survival benefit with ramucirumab in urothelial cancer in the RANGE trial.
Not available
S-EPMC8987042 | biostudies-literature
UnknownA solution scan of societal options to reduce transmission and spread of respiratory viruses: SARS-CoV-2 as a case study.
Not available
S-EPMC8440234 | biostudies-literature
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