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TranscriptomicsSingle cell RNA on hemocytes from wandering larvae of Drosophila melanogaster not infested and infested by Leptopilina boulardi
We aimed at characterizing the diverse hemocyte populations present in the hemolymph of the Drosophila larvae. The hemocytes were collected from wandering larvae infested by wasp (WI) or not infested (NI). The hemocytes were then sequenced using 10x genomics technology.
ORGANISM(S): Drosophila melanogaster 
2020-03-12 | E-MTAB-8698 | biostudies-arrayexpress
TranscriptomicsLamin A/C Is Required For ChAT-Dependent Neuroblastoma Differentiation: a microarray gene expression study
The mouse neuroblastoma N18TG2 clone is unable to differentiate and defective for the enzymes of the biosynthesis of neurotransmitters. The forced expression of choline acetyltransferase (ChAT) in these cells results in the synthesis and release of acetylcholine (Ach) and hence in the expression of ...
ORGANISM(S): Mus musculus 
2017-04-18 | E-GEOD-73591 | biostudies-arrayexpress
TranscriptomicsBulk RNAseq on hemocytes from stage 16 embryos and wandering 3rd instar larvae of Drosophila melanogaster
The aim of this experiment is to compare the transcriptome of Drosophila hemocytes at two developmental stages: in stage 16 embryo, mostly free from any immune challenge and in larvae, which grow in bacteria rich environment. Transgenes inducing the expression of RFP in the hemocytes were used to so...
ORGANISM(S): Drosophila melanogaster 
2020-03-12 | E-MTAB-8702 | biostudies-arrayexpress
TranscriptomicsMolecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres
Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset disorder characterized by ptosis, dysphagia and proximal limb weakness. Autosomal-dominant OPMD is caused by a short (GCG)8–13 expansions within the first exon of the poly(A)-binding protein nuclear 1 gene (PABPN1), leading to an expanded p...
ORGANISM(S): Mus musculus 
2011-01-14 | E-GEOD-26604 | biostudies-arrayexpress
TranscriptomicsThe effect of bisphenol A on human preadipocyte differentiation.
Background: Exposure to the endocrine-disrupting chemical bisphenol A (BPA) is correlated with obesity and promotes adipogenesis of human preadipocytes into mature adipocytes. However, the mechanism of action of BPA-induced human adipogenesis in vitro remains to be fully characterized. Methods: In t...
ORGANISM(S): Homo sapiens 
2014-04-15 | E-GEOD-56085 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Acute Myeloid Leukaemia (AML) cells following co-culture with anti-CD44. RNA-seq of anti-CD44 treated, paired, attached, detached and cells in monoculture using two AML cell lines, KG1a and OCI-AML3
Although 80% of AML patients can initially achieve a complete remission, the long-term disease-free survival is only 40% at 6 years with a 10% 5-year survival rate from first relapse. Most patients do not achieve a second remission. Therefore, relapse after initial response to chemotherapy remains a...
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-14052 | biostudies-arrayexpress
TranscriptomicsTime-course transcriptome analysis of a human neuronal cell line with RFX2 KO
RNA-seq analysis on a human neuronal cell line derived from fetal mesencephalon (LUHMES) wild type and RFX2 knockout from day 0 to day 6.
ORGANISM(S): Homo sapiens 
2024-01-31 | E-MTAB-11546 | biostudies-arrayexpress
TranscriptomicsExpression profiles in 3 different B-cell lymphoma cell lines treated by 92 FDA approved compounds
Identifying the Mechanism of Action (MoA) of drugs is critical for the development of new drugs, understanding their side effects, and drug repositioning. However, identifying drug MoA has been challenging and has been traditionally attempted only though large experimental setups with little success...
ORGANISM(S): Homo sapiens 
2015-07-08 | E-GEOD-60408 | biostudies-arrayexpress
TranscriptomicsEffects of pulp and paper mill effluents on gene expression in the fathead minnow hypothalamus
We evaluated the possible mechanisms by which exposures to pulp and paper mill effluents gene expression in the fathead minnow hypothalamus Keywords: Toxicology Sexually mature fathead minnows were exposed to 100% pulp and paper mill effluents for 5 days. Tanks contained 4 females and 2 males. A ...
ORGANISM(S): Pimephales promelas 
2010-07-07 | E-GEOD-17130 | biostudies-arrayexpress
TranscriptomicsThe inflammatory response of human airway smooth muscle cells
Background: Tissue remodeling induced by airway inflammation is a main trigger of pathogenesis in various chronic lung diseases like asthma, COPD, IPF, and pulmonary hypertension. The role of human airway smooth muscle cells (HASMCs) in this context is unclear. Hypothesis: HASMCs participate in lin...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-45251 | biostudies-arrayexpress
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