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Cullin-5 RING E3 ligase limits CD8 T-cell persistence and effector responses during chronic antigen stimulation [CRISPR Screen]
Cullin-5 RING E3 ligase limits CD8 T-cell persistence and effector responses during chronic antigen stimulation [RNA-seq]

Desmoplastic melanoma (DM) is a rare subtype of melanoma characterized by dense fibrous stroma, resistance to chemotherapy and a lack of actionable driver mutations, but is highly associated with ultraviolet light DNA damage. We analysed 60 patients with advanced DM treated with programmed cell d...

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