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UnknownPreclinical Trials of Cancer Stem Cells Targeted by Metal-Based Coordination Complexes: A Systematic Review.
Background/Objective: Cancer stem cells (CSCs) are a self-renewing subpopulation within tumors that contribute to heterogeneity and resistance to conventional cancer therapies, including chemotherapy and radiotherapy. Despite growing interest in CSCs as therapeutic targets, effective compound...
S-EPMC12299093 | biostudies-literature
UnknownIs the Intergenic Region of Aedes aegypti Totivirus a Recombination Hotspot?
The genus totivirus in the family Totiviridae contains double-stranded RNA viruses. Their genome has two open reading frames (ORFs) that encode capsid protein (CP) and RNA-dependent RNA polymerase (RdRp). The toti-like viruses recently identified in Anopheles sp. and Aedes ae...
S-EPMC9699231 | biostudies-literature
UnknownPredictive Accuracy of the Quick Sepsis-related Organ Failure Assessment Score in Brazil. A Prospective Multicenter Study.
Rationale: Although proposed as a clinical prompt to sepsis based on predictive validity for mortality, the Quick Sepsis-related Organ Failure Assessment (qSOFA) score is often used as a screening tool, which requires high sensitivity.Objectives: To assess the predictive accuracy of qS...
S-EPMC7124712 | biostudies-literature
UnknownIn-hospital mortality and severe outcomes after hospital discharge due to COVID-19: A prospective multicenter study from Brazil.

Background

We evaluated in-hospital mortality and outcomes incidence after hospital discharge due to COVID-19 in a Brazilian multicenter cohort.

Methods

This prospective multicenter study (RECOVER-SUS, NCT04807699) included COVID-19 patients hospitalized in public tertiary hospitals i...
S-EPMC9001143 | biostudies-literature
UnknownLiposome-Encapsulated Morphine Affords a Prolonged Analgesia While Facilitating Extinction of Reward and Aversive Memories.
Morphine is thoroughly used for pain control; however, it has a high addictive potential. Opioid liposome formulations produce controlled drug release and have been thoroughly tested for pain treatment although their role in addiction is still unknown. This study investigated the effects of free mor...
S-EPMC6764324 | biostudies-literature
UnknownSex-dependent effects of forced exercise in the body composition of adolescent rats.
Determining the body composition during adolescence can predict diseases such as obesity, diabetes, and metabolic syndromes later in life; and physical activity became an effective way to restore changes in body composition. However, current available literature assessing the body composition before...
S-EPMC8115159 | biostudies-literature
UnknownDeciphering cartilage neuro-immune interactions and innervation profile through 3D engineered osteoarthritic micropathophysiological system.
Osteoarthritis (OA) is an inflammatory musculoskeletal disorder that results in cartilage breakdown and alterations in the surrounding tissue microenvironment. Imbalances caused by inflammation and catabolic processes potentiate pathological nerves and blood vessels outgrowth toward damaged areas le...
S-EPMC11786692 | biostudies-literature
UnknownIntegrative bioacoustics discrimination of eight delphinid species in the western South Atlantic Ocean.
This study presents an integrative bioacoustics approach to discriminate eight species of odontocetes found on the outer continental shelf and slope of the western South Atlantic Ocean. Spinner, Atlantic spotted, rough-toothed, Risso's, bottlenose, short-beaked common dolphins, killer and long-finne...
S-EPMC6553770 | biostudies-literature
UnknownProsomeric Hypothalamic Distribution of Tyrosine Hydroxylase Positive Cells in Adolescent Rats.
Most of the studies on neurochemical mapping, connectivity, and physiology in the hypothalamic region were carried out in rats and under the columnar morphologic paradigm. According to the columnar model, the entire hypothalamic region lies ventrally within the diencephalon, which includes preoptic,...
S-EPMC9121318 | biostudies-literature
UnknownTiming of exercise differentially impacts adipose tissue gain in male adolescent rats.

Objective

Circadian rhythms of metabolic, hormonal, and behavioral fluctuations and their alterations can impact health. An important gap in knowledge in the field is whether the time of the day of exercise and the age of onset of exercise exert distinct effects at the level of whole-body ad...
S-EPMC11810837 | biostudies-literature
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