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MetabolomicsMultiomic analysis revealed the potential role of rumen microbes in heat stress

Heat stress is an important issue in dairy cattle feeding management affecting summer health and economic efficiency. In recent years, global climate change has led to an increase in atmospheric CO2 content and average daily temperature, making heat stress a major challenge in dairy farming. This...

2022-08-11 | MTBLS5132 | MetaboLights
MetabolomicsModulation of liver metabolism and gut microbiota by Alhagi-honey alleviated heat stress-induced liver damage

Alhagi-honey (AH) is a well-established traditional ethnic medicine with advantageous effects against diarrhea and headaches. We aim to explore the preventive effect of AH on liver damage induced by heat stress (HS) and its underlying mechanism. HS models were established by thermostat, and mice ...

2024-09-23 | MTBLS10021 | MetaboLights
MetabolomicsLactobacillus plantarum MR1 alleviates high-carbohydrate diet-induced oxidative stress and liver lipid deposition via upregulating uridine synthesis
The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear. Here, we demonstrated that a strain affiliated with Lactobacillus plantarum (de...
2024-01-16 | MTBLS4262 | MetaboLights
MetabolomicsOGFOD1 enables AML chemo- and nutrient stress resistance by regulating protein synthesis

Acute Myeloid Leukemia (AML) commonly relapses after initial chemotherapy response. We assessed metabolic adaptations in chemoresistant cells in vivo before overt relapse, identifying altered branched-chain amino acid (BCAA) levels in patient-derived xenografts (PDX) and immunophenotypically iden...

2025-07-19 | MTBLS10255 | MetaboLights
MetabolomicsProbiotics alleviated heat stress-induced spermatogenesis dysfunction by remodeling gut microbiota and producing arginine and pantothenic acid

BACKGROUND: Large-scale farms struggle to effectively address summer heat stress (HS) in dairy goats, which impairs spermatogenesis and reduces reproductive performance by compromising gut and reproductive organ health in male animals. Although Clostridium butyricum (CB) and Enterococcus faecium ...

2025-07-31 | MTBLS12573 | MetaboLights
MetabolomicsPKA regulates stress granule maturation to allow timely recovery after prolonged starvation
Cells have evolved multiple strategies to survive environmental stress conditions. This includes the formation of membrane-less cytoplasmic ribonucleoprotein structures called stress granules that sequester and protect mRNAs encoding many housekeeping genes. Stress granules are not static biomolecul...
2026-06-16 | MTBLS13923 | MetaboLights
MetabolomicsPb Stress and Ectomycorrhizas: Strong Protective Proteomic Responses in Poplar Roots Inoculated with Paxillus involutus Isolate and Characterized by Low Root Colonization Intensity
The commonly observed increased heavy metal tolerance of ectomycorrhized plants is usually linked with the protective role of the fungal hyphae covering colonized plant root tips. However, the molecular tolerance mechanisms in heavy metal stressed low-colonized ectormyocrrhizal plants characterized ...
2022-01-11 | MTBLS1847 | MetaboLights
MetabolomicsPlants establish metabolic crosstalk with Pseudomonas for enhancing herbicide-stress resistance
Although it is known that plants can recruit beneficial rhizobacteria under various stresses, the mechanisms underlying their synergistic interaction in regulating plant resistance remain poorly understood. This study demonstrates that plants establish metabolic crosstalk with Pseudomonas for enhanc...
2026-09-12 | MTBLS15629 | MetaboLights
MetabolomicsPlants establish metabolic crosstalk with Pseudomonas for enhancing herbicide-stress resistance
Although it is known that plants can recruit beneficial rhizobacteria under various stresses, the mechanisms underlying their synergistic interaction in regulating plant resistance remain poorly understood. This study demonstrates that plants establish metabolic crosstalk with Pseudomonas for enhanc...
2026-09-12 | MTBLS15630 | MetaboLights
MetabolomicsPlants establish metabolic crosstalk with Pseudomonas for enhancing herbicide-stress resistance
Although it is known that plants can recruit beneficial rhizobacteria under various stresses, the mechanisms underlying their synergistic interaction in regulating plant resistance remain poorly understood. This study demonstrates that plants establish metabolic crosstalk with Pseudomonas for enhanc...
2026-09-12 | MTBLS15622 | MetaboLights
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